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The Role of Mitochondrial Dynamics i...
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Van Andel Research Institute.
The Role of Mitochondrial Dynamics in Stress Resistance and Neurodegeneration.
紀錄類型:
書目-語言資料,手稿 : Monograph/item
正題名/作者:
The Role of Mitochondrial Dynamics in Stress Resistance and Neurodegeneration./
作者:
Machiela, Emily.
面頁冊數:
1 online resource (171 pages)
附註:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Contained By:
Dissertation Abstracts International79-10B(E).
標題:
Cellular biology. -
電子資源:
click for full text (PQDT)
ISBN:
9780355940879
The Role of Mitochondrial Dynamics in Stress Resistance and Neurodegeneration.
Machiela, Emily.
The Role of Mitochondrial Dynamics in Stress Resistance and Neurodegeneration.
- 1 online resource (171 pages)
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Thesis (Ph.D.)--Van Andel Research Institute, 2018.
Includes bibliographical references
Mitochondria are dynamic, double-membraned organelles responsible for many processes within the cell, including ATP production, calcium buffering, and the stress response. Mitochondria are highly networked throughout the cell and can change shape and size to respond to the energy and stress demands of the cell. These changes are governed by the processes of mitochondrial fission and fusion. Disruptions in mitochondrial dynamics play a role in a variety of diseases, including neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's disease (HD). How these deficits contribute to cellular pathology, however, is still largely unknown. In this work, we investigated the role of mitochondrial morphology and function in stress resistance and neurodegeneration in the nematode C. elegans. We found, using in vivo imaging of the mitochondria, that mitochondrial networks fragment in response to different stresses. Furthermore, mutations in mitochondrial fission and fusion genes alter stress resistance. We also found that in models of PD, dysfunctional mitochondria accumulate with age, and disruption of the mitochondrial unfolded protein response decreases lifespan and worsens phenotypes in these worms. Finally, we also found disrupted mitochondrial networks in worm models of HD and uncover novel mitochondrial targets in HD models that increase lifespan and improve physiologic rates. This work demonstrates the importance of mitochondrial dynamics and function in stress resistance and neurodegenerative disease and identifies novel targets for neurodegenerative disease focusing on mitochondrial dysfunction.
Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018
Mode of access: World Wide Web
ISBN: 9780355940879Subjects--Topical Terms:
1148666
Cellular biology.
Index Terms--Genre/Form:
554714
Electronic books.
The Role of Mitochondrial Dynamics in Stress Resistance and Neurodegeneration.
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Mitochondria are dynamic, double-membraned organelles responsible for many processes within the cell, including ATP production, calcium buffering, and the stress response. Mitochondria are highly networked throughout the cell and can change shape and size to respond to the energy and stress demands of the cell. These changes are governed by the processes of mitochondrial fission and fusion. Disruptions in mitochondrial dynamics play a role in a variety of diseases, including neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's disease (HD). How these deficits contribute to cellular pathology, however, is still largely unknown. In this work, we investigated the role of mitochondrial morphology and function in stress resistance and neurodegeneration in the nematode C. elegans. We found, using in vivo imaging of the mitochondria, that mitochondrial networks fragment in response to different stresses. Furthermore, mutations in mitochondrial fission and fusion genes alter stress resistance. We also found that in models of PD, dysfunctional mitochondria accumulate with age, and disruption of the mitochondrial unfolded protein response decreases lifespan and worsens phenotypes in these worms. Finally, we also found disrupted mitochondrial networks in worm models of HD and uncover novel mitochondrial targets in HD models that increase lifespan and improve physiologic rates. This work demonstrates the importance of mitochondrial dynamics and function in stress resistance and neurodegenerative disease and identifies novel targets for neurodegenerative disease focusing on mitochondrial dysfunction.
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