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Organelle contact sites = from molecular mechanism to disease /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Organelle contact sites/ edited by Mitsuo Tagaya, Thomas Simmen.
Reminder of title:	from molecular mechanism to disease /
other author:	Tagaya, Mitsuo.
Published:	Singapore :Springer Singapore : : 2017.,
Description:	viii, 257 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Cell membranes - Metabolism. -
Online resource:	http://dx.doi.org/10.1007/978-981-10-4567-7
ISBN:	9789811045677

Organelle contact sites = from molecular mechanism to disease /
Organelle contact sitesfrom molecular mechanism to disease /[electronic resource] :edited by Mitsuo Tagaya, Thomas Simmen. - Singapore :Springer Singapore :2017. - viii, 257 p. :ill., digital ;24 cm. - Advances in experimental medicine and biology,v.9970065-2598 ;. - Advances in experimental medicine and biology ;780..

Part 1: Overview of Organelle Contacts -- Chapter 1: Organelle Communication at Membrane Contact Sites (MCS): From Curiosity to Center Stage in Cell Biology and Biomedical Research -- Part 2: Organization and Roles of Organelle Contact Sites -- Chapter 2: Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs) -- Chapter 3: Regulation of mitochondrial dynamics and autophagy by the mitochondria-associated membrane -- Chapter 4: Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ signaling: the importance of mitochondria associated membranes (MAMs) -- Chapter 5: Ceramide transport from the endoplasmic reticulum to the trans Golgi region at organelle membrane contact sites -- Chapter 6: Endoplasmic Reticulum - Plasma Membrane cross-talk mediated by the extended synaptotagmins -- Chapter 7: Endoplasmic Reticulum-Plasma membrane contacts regulate cellular excitability -- Chapter 8: The lipid droplet and the endoplasmic reticulum -- Chapter 9: Role of intra- and inter-mitochondrial membrane contact sites in yeast phospholipid biogenesis -- Chapter 10: Discovery and roles of ER-endolysosomal contact sites in disease -- Part 3: Infection and Disease -- Chapter 11: Alzheimer disease -- Chapter 12: Mitochondrial-associated membranes in Parkinson's disease -- Chapter 13: Role of endoplasmic reticulum-mitochondria communication in type 2 diabetes -- Chapter 14: Mitochondria-endoplasmic reticulum contact sites mediate innate immune responses -- Chapter 15: Hepatitis C Virus Replication -- Chapter 16: Hijacking of Membrane Contact Sites by Intracellular Bacterial Pathogens -- Chapter 17: Alterations in Ca2+ signalling via ER-mitochondria contact site remodelling in cancer.

This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.

ISBN: 9789811045677

Standard No.: 10.1007/978-981-10-4567-7doiSubjects--Topical Terms:

1199718
Cell membranes
--Metabolism.

LC Class. No.: QH601

Dewey Class. No.: 574.875

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520 $a This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.
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