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Proteases in physiology and pathology

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Proteases in physiology and pathology/ edited by Sajal Chakraborti, Naranjan S. Dhalla.
other author:	Chakraborti, Sajal.
Published:	Singapore :Springer Singapore : : 2017.,
Description:	xv, 619 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Proteolytic enzymes. -
Online resource:	http://dx.doi.org/10.1007/978-981-10-2513-6
ISBN:	9789811025136

Proteases in physiology and pathology
Proteases in physiology and pathology[electronic resource] /edited by Sajal Chakraborti, Naranjan S. Dhalla. - Singapore :Springer Singapore :2017. - xv, 619 p. :ill., digital ;24 cm.

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.

ISBN: 9789811025136

Standard No.: 10.1007/978-981-10-2513-6doiSubjects--Topical Terms:

796650
Proteolytic enzymes.

LC Class. No.: QP609.P78

Dewey Class. No.: 572.76

Proteases in physiology and pathology
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520 $a Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.
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