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Voltage-gated sodium channels = structure, function and channelopathies /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Voltage-gated sodium channels/ edited by Mohamed Chahine.
其他題名:	structure, function and channelopathies /
其他作者:	Chahine, Mohamed.
出版者:	Cham :Springer International Publishing : : 2018.,
面頁冊數:	x, 450 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Sodium channels. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-90284-5
ISBN:	9783319902845

Voltage-gated sodium channels = structure, function and channelopathies /
Voltage-gated sodium channelsstructure, function and channelopathies /[electronic resource] :edited by Mohamed Chahine. - Cham :Springer International Publishing :2018. - x, 450 p. :ill. (some col.), digital ;24 cm. - Handbook of experimental pharmacology,v.2460171-2004 ;. - Handbook of experimental pharmacology ;v.212..

Preface -- Part I -- Evolution of voltage-gated sodium channels -- 1. Evolutionary History of Voltage-Gated Sodium Channels -- 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function -- 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective -- 4. The Cardiac Sodium Channel and Its Protein Partners -- 5. : Posttranslational Modification of Sodium Channels -- 6. Sodium Channel Trafficking -- 7. pH Modulation of Voltage-Gated Sodium Channels -- 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C -- Part III. Drugs and toxins interactions with sodium channels -- 9. Toxins That Affect Voltage-Gated Sodium Channels -- 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels -- 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels -- 12. Structural Models of Ligand-Bound Sodium Channels -- 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7 -- Part IV. Pathophysiology of sodium channels -- 14. Sodium Channelopathies of Skeletal Muscle -- 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction -- 16. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain -- 17. Gating Pore Currents in Sodium Channels -- 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells -- 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases.

This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

ISBN: 9783319902845

Standard No.: 10.1007/978-3-319-90284-5doiSubjects--Topical Terms:

674252
Sodium channels.

LC Class. No.: QP356.2

Dewey Class. No.: 573.848

Voltage-gated sodium channels = structure, function and channelopathies /
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