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Rethinking platinum anticancer drug design = towards targeted and immuno-chemotherapeutic approaches /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Rethinking platinum anticancer drug design/ by Daniel Yuan Qiang Wong.
Reminder of title:	towards targeted and immuno-chemotherapeutic approaches /
Author:	Wong, Daniel Yuan Qiang.
Published:	Singapore :Springer Singapore : : 2018.,
Description:	xxx, 147 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Cancer - Chemotherapy. -
Online resource:	http://dx.doi.org/10.1007/978-981-10-8594-9
ISBN:	9789811085949

Rethinking platinum anticancer drug design = towards targeted and immuno-chemotherapeutic approaches /
Wong, Daniel Yuan Qiang.

Rethinking platinum anticancer drug designtowards targeted and immuno-chemotherapeutic approaches /[electronic resource] :by Daniel Yuan Qiang Wong. - Singapore :Springer Singapore :2018. - xxx, 147 p. :ill. (some col.), digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction- Cisplatin- Now and Future -- Harnessing Chemoselective Imine Ligation for Tethering Bioactive Molecules to Platinum (IV) Prodrugs -- Probing the Platinum(IV) Prodrug Hypothesis - Are Platinum(IV) Complexes Really Prodrugs of Cisplatin? -- Induction of Targeted Necrosis with HER2-Targeted Platinum(IV) Anticancer Prodrugs -- Immuno-Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents -- Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes -- Concluding Remarks.

This thesis describes the authors' pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outcome for patients. Historically, the contribution of the immune system to chemotherapy outcomes has been neglected, as anticancer drugs were believed to be immunosuppressive. However, this has been challenged by contemporary evidence suggesting that many chemotherapeutics, including platinum-based agents, stimulate the innate and/or adaptive immune system and that these "secret allies" contribute tangibly to clinical outcomes. A multi-pronged immuno-chemotherapeutic approach not only shrinks tumors, but more importantly, reactivate dormant immune responses to malignancies, eliminating residual cancer cells.

ISBN: 9789811085949

Standard No.: 10.1007/978-981-10-8594-9doiSubjects--Topical Terms:

645264
Cancer
--Chemotherapy.

LC Class. No.: RC271.C5 / W664 2018

Dewey Class. No.: 616.994061

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520 $a This thesis describes the authors' pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outcome for patients. Historically, the contribution of the immune system to chemotherapy outcomes has been neglected, as anticancer drugs were believed to be immunosuppressive. However, this has been challenged by contemporary evidence suggesting that many chemotherapeutics, including platinum-based agents, stimulate the innate and/or adaptive immune system and that these "secret allies" contribute tangibly to clinical outcomes. A multi-pronged immuno-chemotherapeutic approach not only shrinks tumors, but more importantly, reactivate dormant immune responses to malignancies, eliminating residual cancer cells.
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