國立虎尾科技大學 |

Inflammatory mechanisms in mediating hearing loss

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Inflammatory mechanisms in mediating hearing loss/ edited by Vickram Ramkumar, Leonard P. Rybak.
other author:	Ramkumar, Vickram.
Published:	Cham :Springer International Publishing : : 2018.,
Description:	x, 231 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Deafness. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-92507-3
ISBN:	9783319925073

Inflammatory mechanisms in mediating hearing loss
Inflammatory mechanisms in mediating hearing loss[electronic resource] /edited by Vickram Ramkumar, Leonard P. Rybak. - Cham :Springer International Publishing :2018. - x, 231 p. :ill., digital ;24 cm.

Preface -- The Cochlea -- Oxidative Stress and Hearing Loss -- Corticotropin Releasing Factor Signaling in the Mammalian Cochlea: An Integrative Niche for Cochlear Homeostatic Balance Against Noise -- Cochlear vascular pathology and hearing loss -- Cochlear Inflammation Associated with Noise-Exposure -- Middle Ear Infection and Hearing Loss -- Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss -- The Contribution of Anti-Oxidant and Anti-Inflammatory Functions of Adenosine A1 Receptor In Mediating Otoprotection -- Anti-inflammatory therapies for sensorineural hearing loss -- Implementation and Outcomes of Clinical Trials in Immune-Mediated Hearing Loss and other Rare Diseases -- Index.

The primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this process translates into cochlear inflammation. Basic cellular mechanisms underlying the contribution of oxidant stress to hearing loss will be explained and molecular pathways leading to inflammatory processes will be outlined. Several different aspects of the cochlear inflammatory process will be discussed in detail. These include the sources of inflammatory cells, chemokines, inflammatory cytokines and the roles of cochlear resident immune cells in mediating hearing loss. In addition, evidence for a robust cochlear-based steroid axis which is activated by cochlear stress and serves a protective system. The role of the strial vasculature networks which aid in maintenance of the blood-labyrinth barrier and control the entry of circulating immune cells into the cochlea will be described. Molecular pathways leading to activation of the local inflammatory process will be highlighted and otoprotective treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-tympanic steroids and other drugs will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss. It is our hope that this book would provide a better understanding of the interaction of oxidative stress and inflammation in hearing loss. This book should provide basic information to scientists in the field of auditory research and to enlighten clinicians who treat patients with potentially ototoxic drugs.

ISBN: 9783319925073

Standard No.: 10.1007/978-3-319-92507-3doiSubjects--Topical Terms:

871262
Deafness.

LC Class. No.: RF290 / .I545 2018

Dewey Class. No.: 617.8

Inflammatory mechanisms in mediating hearing loss
LDR:03402nam a2200313 a 4500 001 927522
003 DE-He213
005 20190122103503.0
006 m d
007 cr nn 008maaau
008 190626s2018 gw s 0 eng d
020 $a 9783319925073 $q (electronic bk.)
020 $a 9783319925066 $q (paper)
024 7 $a 10.1007/978-3-319-92507-3 $2 doi
035 $a 978-3-319-92507-3
040 $a GP $c GP
041 0 $a eng
050 4 $a RF290 $b .I545 2018
072 7 $a PSAN $2 bicssc
072 7 $a MED057000 $2 bisacsh
082 0 4 $a 617.8 $2 23
090 $a RF290 $b .I43 2018
245 0 0 $a Inflammatory mechanisms in mediating hearing loss $h [electronic resource] / $c edited by Vickram Ramkumar, Leonard P. Rybak.
260 $a Cham : $c 2018. $b Springer International Publishing : $b Imprint: Springer,
300 $a x, 231 p. : $b ill., digital ; $c 24 cm.
505 0 $a Preface -- The Cochlea -- Oxidative Stress and Hearing Loss -- Corticotropin Releasing Factor Signaling in the Mammalian Cochlea: An Integrative Niche for Cochlear Homeostatic Balance Against Noise -- Cochlear vascular pathology and hearing loss -- Cochlear Inflammation Associated with Noise-Exposure -- Middle Ear Infection and Hearing Loss -- Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss -- The Contribution of Anti-Oxidant and Anti-Inflammatory Functions of Adenosine A1 Receptor In Mediating Otoprotection -- Anti-inflammatory therapies for sensorineural hearing loss -- Implementation and Outcomes of Clinical Trials in Immune-Mediated Hearing Loss and other Rare Diseases -- Index.
520 $a The primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this process translates into cochlear inflammation. Basic cellular mechanisms underlying the contribution of oxidant stress to hearing loss will be explained and molecular pathways leading to inflammatory processes will be outlined. Several different aspects of the cochlear inflammatory process will be discussed in detail. These include the sources of inflammatory cells, chemokines, inflammatory cytokines and the roles of cochlear resident immune cells in mediating hearing loss. In addition, evidence for a robust cochlear-based steroid axis which is activated by cochlear stress and serves a protective system. The role of the strial vasculature networks which aid in maintenance of the blood-labyrinth barrier and control the entry of circulating immune cells into the cochlea will be described. Molecular pathways leading to activation of the local inflammatory process will be highlighted and otoprotective treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-tympanic steroids and other drugs will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss. It is our hope that this book would provide a better understanding of the interaction of oxidative stress and inflammation in hearing loss. This book should provide basic information to scientists in the field of auditory research and to enlighten clinicians who treat patients with potentially ototoxic drugs.
650 0 $a Deafness. $3 871262
650 1 4 $a Biomedicine. $3 593880
650 2 4 $a Neurosciences. $3 593561
650 2 4 $a Otorhinolaryngology. $3 668435
700 1 $a Ramkumar, Vickram. $3 1206888
700 1 $a Rybak, Leonard P. $3 1206889
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-92507-3
950 $a Biomedical and Life Sciences (Springer-11642)