國立虎尾科技大學 |

Mathematical modeling of protein complexes

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Mathematical modeling of protein complexes/ by Tatiana Koshlan, Kirill Kulikov.
作者:	Koshlan, Tatiana.
其他作者:	Kulikov, Kirill.
出版者:	Cham :Springer International Publishing : : 2018.,
面頁冊數:	xiv, 367 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Proteins - Mathematical models. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-98304-2
ISBN:	9783319983042

Mathematical modeling of protein complexes
Koshlan, Tatiana.

Mathematical modeling of protein complexes[electronic resource] /by Tatiana Koshlan, Kirill Kulikov. - Cham :Springer International Publishing :2018. - xiv, 367 p. :ill., digital ;24 cm. - Biological and medical physics, biomedical engineering,1618-7210. - Biological and medical physics, biomedical engineering..

Introduction -- Physical methods for studying proteins -- Physical properties of amino acids and proteins -- Selection of a biological objects -- Mathematical simulation of complex formation of protein molecules allowing for their domain structure -- Mathematical modeling of histone dimers formation in vitro with solutions of different ionic strength in the presence of monovalent salts -- Mathematical modeling of the temperature effect on binding of monomeric proteins in aqueous solutions by example on histones H2A, H2B, H3 and H4 -- Mathematical modeling of the temperature effect on binding of different sites of protein BCL-XL in aqueous solutions -- Mathematical modeling of the phosphorylation effect on the nature formation of biological complexes P53-MDM2 and P53-P300.

This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducing the number of measurements required according to the developed criteria. These models make it possible to reach a conclusion about the interactions between different amino acid chains and to identify more stable sites on proteins. The models also take the phosphorylation of amino acid residues into account. At the end of the book, the authors present possible directions of application of their physical and mathematical models in clinical medicine.

ISBN: 9783319983042

Standard No.: 10.1007/978-3-319-98304-2doiSubjects--Topical Terms:

720671
Proteins
--Mathematical models.

LC Class. No.: QP551 / .K674 2018

Dewey Class. No.: 572.6015118

Mathematical modeling of protein complexes
LDR:02595nam a2200337 a 4500 001 928734
003 DE-He213
005 20190305145239.0
006 m d
007 cr nn 008maaau
008 190626s2018 gw s 0 eng d
020 $a 9783319983042 $q (electronic bk.)
020 $a 9783319983035 $q (paper)
024 7 $a 10.1007/978-3-319-98304-2 $2 doi
035 $a 978-3-319-98304-2
040 $a GP $c GP
041 0 $a eng
050 4 $a QP551 $b .K674 2018
072 7 $a PHVN $2 bicssc
072 7 $a PHVD $2 bicssc
072 7 $a SCI009000 $2 bisacsh
082 0 4 $a 572.6015118 $2 23
090 $a QP551 $b .K86 2018
100 1 $a Koshlan, Tatiana. $3 1206649
245 1 0 $a Mathematical modeling of protein complexes $h [electronic resource] / $c by Tatiana Koshlan, Kirill Kulikov.
260 $a Cham : $c 2018. $b Springer International Publishing : $b Imprint: Springer,
300 $a xiv, 367 p. : $b ill., digital ; $c 24 cm.
490 1 $a Biological and medical physics, biomedical engineering, $x 1618-7210
505 0 $a Introduction -- Physical methods for studying proteins -- Physical properties of amino acids and proteins -- Selection of a biological objects -- Mathematical simulation of complex formation of protein molecules allowing for their domain structure -- Mathematical modeling of histone dimers formation in vitro with solutions of different ionic strength in the presence of monovalent salts -- Mathematical modeling of the temperature effect on binding of monomeric proteins in aqueous solutions by example on histones H2A, H2B, H3 and H4 -- Mathematical modeling of the temperature effect on binding of different sites of protein BCL-XL in aqueous solutions -- Mathematical modeling of the phosphorylation effect on the nature formation of biological complexes P53-MDM2 and P53-P300.
520 $a This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducing the number of measurements required according to the developed criteria. These models make it possible to reach a conclusion about the interactions between different amino acid chains and to identify more stable sites on proteins. The models also take the phosphorylation of amino acid residues into account. At the end of the book, the authors present possible directions of application of their physical and mathematical models in clinical medicine.
650 0 $a Proteins $x Mathematical models. $3 720671
650 1 4 $a Physics. $3 564049
650 2 4 $a Biological and Medical Physics, Biophysics. $3 1113305
650 2 4 $a Protein Structure. $3 782128
650 2 4 $a Numerical and Computational Physics, Simulation. $3 1112293
650 2 4 $a Mathematical and Computational Biology. $3 786706
650 2 4 $a Biomedical Engineering. $3 588771
700 1 $a Kulikov, Kirill. $3 1020497
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a Biological and medical physics, biomedical engineering. $3 639561
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-98304-2
950 $a Physics and Astronomy (Springer-11651)