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Development of antibody-based therap...

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Development of antibody-based therapeutics = translational considerations & challenges /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Development of antibody-based therapeutics/ edited by Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp.
其他題名:	translational considerations & challenges /
其他作者:	Tabrizi, Mohammad A.
出版者:	Singapore :Springer Singapore : : 2018.,
面頁冊數:	viii, 248 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Monoclonal antibodies - Therapeutic use. -
電子資源:	https://doi.org/10.1007/978-981-13-0496-5
ISBN:	9789811304965

Development of antibody-based therapeutics = translational considerations & challenges /
Development of antibody-based therapeuticstranslational considerations & challenges /[electronic resource] :edited by Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp. - 2nd ed. - Singapore :Springer Singapore :2018. - viii, 248 p. :ill., digital ;24 cm.

1. Introduction -- 2. Translational Considerations and Challenges: An Overview -- 3. Considerations for Construct and Affinity Design Goals -- 4. Epitope Characterization and Isotype Selection -- 5. Biophysical Considerations for Development of Antibody-Based Therapeutics -- 6. Novel Technologies for Generation of Bispecific Constructs -- 7. Stimulus-Response Mechanisms: An Overview -- 8. Evaluation of Tumor Growth Inhibition in Preclinical Tumor Models -A Quantitative Approach -- 9. Application of Proof-of-Mechanism Biomarkers (POM) in Design and Development of Biologics Modalities -- 10. Antibody Drug Conjugates: Translational Considerations -- 11. Application of PK-PD Modeling and Simulation Approaches for Immuno-Oncology Drugs -- 12. Translational Biomarkers: Application in the Clinical Development of Combination Therapies.

ISBN: 9789811304965

Standard No.: 10.1007/978-981-13-0496-5doiSubjects--Topical Terms:

892175
Monoclonal antibodies
--Therapeutic use.

LC Class. No.: RM282.M65 / D484 2018

Dewey Class. No.: 615.37

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505 0 $a 1. Introduction -- 2. Translational Considerations and Challenges: An Overview -- 3. Considerations for Construct and Affinity Design Goals -- 4. Epitope Characterization and Isotype Selection -- 5. Biophysical Considerations for Development of Antibody-Based Therapeutics -- 6. Novel Technologies for Generation of Bispecific Constructs -- 7. Stimulus-Response Mechanisms: An Overview -- 8. Evaluation of Tumor Growth Inhibition in Preclinical Tumor Models -A Quantitative Approach -- 9. Application of Proof-of-Mechanism Biomarkers (POM) in Design and Development of Biologics Modalities -- 10. Antibody Drug Conjugates: Translational Considerations -- 11. Application of PK-PD Modeling and Simulation Approaches for Immuno-Oncology Drugs -- 12. Translational Biomarkers: Application in the Clinical Development of Combination Therapies.
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