國立虎尾科技大學 |

Cancer RNome = nature & evolution /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Cancer RNome/ by Mansi Arora, Deepak Kaul.
Reminder of title:	nature & evolution /
Author:	Arora, Mansi.
other author:	Kaul, Deepak.
Published:	Singapore :Springer Singapore : : 2018.,
Description:	xii, 313 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Cancer - Genetic aspects. -
Online resource:	https://doi.org/10.1007/978-981-13-1568-8
ISBN:	9789811315688

Cancer RNome = nature & evolution /
Arora, Mansi.

Cancer RNomenature & evolution /[electronic resource] :by Mansi Arora, Deepak Kaul. - Singapore :Springer Singapore :2018. - xii, 313 p. :ill. (some col.), digital ;24 cm.

1. Section 1. RNome: Evolution and nature -- Chapter. 1.1. RNA world hypothesis -- Chapter.1.2. Various classes of RNAs (coding as well non-coding), their biosynthesis and basic functions -- 2. Section 2. Cellular RNome: Chromatin dynamics -- Chapter. 2.1. Chromatin modifications & transcription -- Chapter. 2.2. RNA modifications and epitranscriptomics -- Chapter. 2.3. Cellular RNome: Contribution of non-coding RNA -- 3. Section 3. Cancer RNome: Evolution and Sustenance.(How is cancer RNome different from RNome of healthy cell? How does the cancer RNome regulate the evolution as well as the sustenance of cancer?) -- Chapter. 3.1. Genome instability and mutation -- Chapter. 3.2. Tumor-promoting inflammation -- Chapter. 3.3. DNA methylation addiction -- Chapter. 3.4. Oncoviruses -- Chapter. 3.5. Sustained proliferative signaling -- Chapter. 3.6. Evasion of growth suppressors -- Chapter. 3.7. Replicative immortality -- Chapter. 3.8. Resisting Cell death -- Chapter. 3.9. Invasion and metastasis -- Chapter. 3.10. Angiogenesis induction -- Chapter. 3.11. Deregulated cellular energetics/Molecular sweet tooth -- Chapter. 3.12. Tumor Immune-evasion -- Chapter. 3.13. Cancer stem cells and tumor cell plasticity -- 4. Section 4. Cancer RNome: Therapeutic implications(Translational implications of the cancer RNome) Chapter. 4.1. RNAs as diagnostic/prognostic biomarkers -- Chapter. 4.2. RNAs in cancer therapy & chemo-resistance.

In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs) This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians.

ISBN: 9789811315688

Standard No.: 10.1007/978-981-13-1568-8doiSubjects--Topical Terms:

782504
Cancer
--Genetic aspects.

LC Class. No.: RC268.4 / .A767 2018

Dewey Class. No.: 616.994042

Cancer RNome = nature & evolution /
LDR:03600nam a2200325 a 4500 001 929507
003 DE-He213
005 20190321111346.0
006 m d
007 cr nn 008maaau
008 190626s2018 si s 0 eng d
020 $a 9789811315688 $q (electronic bk.)
020 $a 9789811315671 $q (paper)
024 7 $a 10.1007/978-981-13-1568-8 $2 doi
035 $a 978-981-13-1568-8
040 $a GP $c GP
041 0 $a eng
050 4 $a RC268.4 $b .A767 2018
072 7 $a MJCL $2 bicssc
072 7 $a MED062000 $2 bisacsh
072 7 $a MJCL $2 thema
082 0 4 $a 616.994042 $2 23
090 $a RC268.4 $b .A769 2018
100 1 $a Arora, Mansi. $3 1210154
245 1 0 $a Cancer RNome $h [electronic resource] : $b nature & evolution / $c by Mansi Arora, Deepak Kaul.
260 $a Singapore : $c 2018. $b Springer Singapore : $b Imprint: Springer,
300 $a xii, 313 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a 1. Section 1. RNome: Evolution and nature -- Chapter. 1.1. RNA world hypothesis -- Chapter.1.2. Various classes of RNAs (coding as well non-coding), their biosynthesis and basic functions -- 2. Section 2. Cellular RNome: Chromatin dynamics -- Chapter. 2.1. Chromatin modifications & transcription -- Chapter. 2.2. RNA modifications and epitranscriptomics -- Chapter. 2.3. Cellular RNome: Contribution of non-coding RNA -- 3. Section 3. Cancer RNome: Evolution and Sustenance.(How is cancer RNome different from RNome of healthy cell? How does the cancer RNome regulate the evolution as well as the sustenance of cancer?) -- Chapter. 3.1. Genome instability and mutation -- Chapter. 3.2. Tumor-promoting inflammation -- Chapter. 3.3. DNA methylation addiction -- Chapter. 3.4. Oncoviruses -- Chapter. 3.5. Sustained proliferative signaling -- Chapter. 3.6. Evasion of growth suppressors -- Chapter. 3.7. Replicative immortality -- Chapter. 3.8. Resisting Cell death -- Chapter. 3.9. Invasion and metastasis -- Chapter. 3.10. Angiogenesis induction -- Chapter. 3.11. Deregulated cellular energetics/Molecular sweet tooth -- Chapter. 3.12. Tumor Immune-evasion -- Chapter. 3.13. Cancer stem cells and tumor cell plasticity -- 4. Section 4. Cancer RNome: Therapeutic implications(Translational implications of the cancer RNome) Chapter. 4.1. RNAs as diagnostic/prognostic biomarkers -- Chapter. 4.2. RNAs in cancer therapy & chemo-resistance.
520 $a In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs) This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians.
650 0 $a Cancer $x Genetic aspects. $3 782504
650 1 4 $a Cancer Research. $3 668358
650 2 4 $a Human Genetics. $3 593893
650 2 4 $a Molecular Medicine. $3 668353
650 2 4 $a Biomedical Engineering/Biotechnology. $3 1068811
650 2 4 $a Laboratory Medicine. $3 673604
700 1 $a Kaul, Deepak. $3 1210155
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
856 4 0 $u https://doi.org/10.1007/978-981-13-1568-8
950 $a Biomedical and Life Sciences (Springer-11642)