語系:
繁體中文
English
說明(常見問題)
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Carbonic anhydrase as drug target = ...
~
Matulis, Daumantas.
Carbonic anhydrase as drug target = thermodynamics and structure of inhibitor binding /
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Carbonic anhydrase as drug target/ edited by Daumantas Matulis.
其他題名:
thermodynamics and structure of inhibitor binding /
其他作者:
Matulis, Daumantas.
出版者:
Cham :Springer International Publishing : : 2019.,
面頁冊數:
xxvi, 353 p. :ill., digital ; : 24 cm.;
Contained By:
Springer eBooks
標題:
Carbonic anhydrase. -
電子資源:
https://doi.org/10.1007/978-3-030-12780-0
ISBN:
9783030127800
Carbonic anhydrase as drug target = thermodynamics and structure of inhibitor binding /
Carbonic anhydrase as drug target
thermodynamics and structure of inhibitor binding /[electronic resource] :edited by Daumantas Matulis. - Cham :Springer International Publishing :2019. - xxvi, 353 p. :ill., digital ;24 cm.
Final ToC tbd. 1) Description of human carbonic anhydrases (12 catalytically active human isoforms; isoforms as drug targets, enzymatic activity, catalytic mechanism, thermodynamics of protonation of the water molecule in the active site) -- 2) Thermal stabilities of all isoform CA catalytic domains -- Thermodynamics of inhibitor binding to CAs (incl. intrinsic thermodynamics - not mentioned important subject in most CA literature) -- 3) Comparison of methods to determine inhibitor binding to CAs (ITC, FTSA, enzymatic activity assays) -- 4) Chemical synthesis of CA inhibitors -- 5) X-ray crystallographic structures of CAs and their complexes with inhibitors -- 6) Antibodies against CAs.
This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also types and chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed.
ISBN: 9783030127800
Standard No.: 10.1007/978-3-030-12780-0doiSubjects--Topical Terms:
1020774
Carbonic anhydrase.
LC Class. No.: QP613.C37 / C373 2019
Dewey Class. No.: 572.7
Carbonic anhydrase as drug target = thermodynamics and structure of inhibitor binding /
LDR
:02868nam a2200337 a 4500
001
940156
003
DE-He213
005
20191016163632.0
006
m d
007
cr nn 008maaau
008
200417s2019 gw s 0 eng d
020
$a
9783030127800
$q
(electronic bk.)
020
$a
9783030127787
$q
(paper)
024
7
$a
10.1007/978-3-030-12780-0
$2
doi
035
$a
978-3-030-12780-0
040
$a
GP
$c
GP
041
0
$a
eng
050
4
$a
QP613.C37
$b
C373 2019
072
7
$a
MBGR
$2
bicssc
072
7
$a
SCI049000
$2
bisacsh
072
7
$a
MBGR
$2
thema
072
7
$a
PSD
$2
thema
082
0 4
$a
572.7
$2
23
090
$a
QP613.C37
$b
C264 2019
245
0 0
$a
Carbonic anhydrase as drug target
$h
[electronic resource] :
$b
thermodynamics and structure of inhibitor binding /
$c
edited by Daumantas Matulis.
260
$a
Cham :
$c
2019.
$b
Springer International Publishing :
$b
Imprint: Springer,
300
$a
xxvi, 353 p. :
$b
ill., digital ;
$c
24 cm.
505
0
$a
Final ToC tbd. 1) Description of human carbonic anhydrases (12 catalytically active human isoforms; isoforms as drug targets, enzymatic activity, catalytic mechanism, thermodynamics of protonation of the water molecule in the active site) -- 2) Thermal stabilities of all isoform CA catalytic domains -- Thermodynamics of inhibitor binding to CAs (incl. intrinsic thermodynamics - not mentioned important subject in most CA literature) -- 3) Comparison of methods to determine inhibitor binding to CAs (ITC, FTSA, enzymatic activity assays) -- 4) Chemical synthesis of CA inhibitors -- 5) X-ray crystallographic structures of CAs and their complexes with inhibitors -- 6) Antibodies against CAs.
520
$a
This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also types and chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed.
650
0
$a
Carbonic anhydrase.
$3
1020774
650
0
$a
Drug targeting.
$3
581035
650
1 4
$a
Molecular Medicine.
$3
668353
650
2 4
$a
Medical Biochemistry.
$3
668897
650
2 4
$a
Protein-Ligand Interactions.
$3
882815
650
2 4
$a
Medicinal Chemistry.
$3
668872
650
2 4
$a
Pharmaceutical Sciences/Technology.
$3
768561
700
1
$a
Matulis, Daumantas.
$3
1226667
710
2
$a
SpringerLink (Online service)
$3
593884
773
0
$t
Springer eBooks
856
4 0
$u
https://doi.org/10.1007/978-3-030-12780-0
950
$a
Biomedical and Life Sciences (Springer-11642)
筆 0 讀者評論
多媒體
評論
新增評論
分享你的心得
Export
取書館別
處理中
...
變更密碼[密碼必須為2種組合(英文和數字)及長度為10碼以上]
登入