國立虎尾科技大學 |

Diabetes mellitus = a risk factor for Alzheimer's disease /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Diabetes mellitus/ edited by Yusaku Nakabeppu, Toshiharu Ninomiya.
其他題名:	a risk factor for Alzheimer's disease /
其他作者:	Nakabeppu, Yusaku.
出版者:	Singapore :Springer Singapore : : 2019.,
面頁冊數:	vi, 248 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Diabetes. -
電子資源:	https://doi.org/10.1007/978-981-13-3540-2
ISBN:	9789811335402

Diabetes mellitus = a risk factor for Alzheimer's disease /
Diabetes mellitusa risk factor for Alzheimer's disease /[electronic resource] :edited by Yusaku Nakabeppu, Toshiharu Ninomiya. - Singapore :Springer Singapore :2019. - vi, 248 p. :ill., digital ;24 cm. - Advances in experimental medicine and biology,11280065-2598 ;. - Advances in experimental medicine and biology ;780..

Chapter 1 Origins of brain insulin and its function -- Chapter 2 Epidemiological evidence of the relationship between diabetes and dementia -- Chapter 3 Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer's Disease Brain -- Chapter 4 The Full Spectrum of Alzheimer's Disease is Rooted in Metabolic -- Derangements That Drive Type 3 Diabetes -- Chapter 5 The roles of apolipoprotein E, lipids and glucose in the pathogenesis of Alzheimer's disease -- Chapter 6 Molecular connection between diabetes and dementia -- Chapter 7 Type II Diabetes mellitus accelerates age-dependent Ab pathology in cynomolgus monkey brain -- Chapter 8 Diabetes-related dementia -- Chapter 9 Tortuous paths of insulin signaling and mitochondria in Alzheimer's disease -- Chapter 10 Mammalian target of rapamycin at the crossroad between Alzheimer's Disease and diabetes -- Chapter 11 Therapeutic strategies for Alzheimer's disease in the view of diabetes mellitus.

This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer's disease (AD) It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.

ISBN: 9789811335402

Standard No.: 10.1007/978-981-13-3540-2doiSubjects--Topical Terms:

582755
Diabetes.

LC Class. No.: RC660 / .D533 2019

Dewey Class. No.: 616.462

Diabetes mellitus = a risk factor for Alzheimer's disease /
LDR:03258nam a2200337 a 4500 001 940194
003 DE-He213
005 20191016154909.0
006 m d
007 cr nn 008maaau
008 200417s2019 si s 0 eng d
020 $a 9789811335402 $q (electronic bk.)
020 $a 9789811335396 $q (paper)
024 7 $a 10.1007/978-981-13-3540-2 $2 doi
035 $a 978-981-13-3540-2
040 $a GP $c GP
041 0 $a eng
050 4 $a RC660 $b .D533 2019
072 7 $a PSAN $2 bicssc
072 7 $a MED057000 $2 bisacsh
072 7 $a PSAN $2 thema
082 0 4 $a 616.462 $2 23
090 $a RC660 $b .D536 2019
245 0 0 $a Diabetes mellitus $h [electronic resource] : $b a risk factor for Alzheimer's disease / $c edited by Yusaku Nakabeppu, Toshiharu Ninomiya.
260 $a Singapore : $c 2019. $b Springer Singapore : $b Imprint: Springer,
300 $a vi, 248 p. : $b ill., digital ; $c 24 cm.
490 1 $a Advances in experimental medicine and biology, $x 0065-2598 ; $v 1128
505 0 $a Chapter 1 Origins of brain insulin and its function -- Chapter 2 Epidemiological evidence of the relationship between diabetes and dementia -- Chapter 3 Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer's Disease Brain -- Chapter 4 The Full Spectrum of Alzheimer's Disease is Rooted in Metabolic -- Derangements That Drive Type 3 Diabetes -- Chapter 5 The roles of apolipoprotein E, lipids and glucose in the pathogenesis of Alzheimer's disease -- Chapter 6 Molecular connection between diabetes and dementia -- Chapter 7 Type II Diabetes mellitus accelerates age-dependent Ab pathology in cynomolgus monkey brain -- Chapter 8 Diabetes-related dementia -- Chapter 9 Tortuous paths of insulin signaling and mitochondria in Alzheimer's disease -- Chapter 10 Mammalian target of rapamycin at the crossroad between Alzheimer's Disease and diabetes -- Chapter 11 Therapeutic strategies for Alzheimer's disease in the view of diabetes mellitus.
520 $a This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer's disease (AD) It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.
650 0 $a Diabetes. $3 582755
650 0 $a Alzheimer's disease $x Risk factors. $3 1226718
650 1 4 $a Neurosciences. $3 593561
650 2 4 $a Neurology. $3 593894
700 1 $a Nakabeppu, Yusaku. $3 1226716
700 1 $a Ninomiya, Toshiharu. $3 1226717
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a Advances in experimental medicine and biology ; $v 780. $3 881230
856 4 0 $u https://doi.org/10.1007/978-981-13-3540-2
950 $a Biomedical and Life Sciences (Springer-11642)