國立虎尾科技大學 |

Dose-finding designs for early-phase cancer clinical trials = a brief guidebook to theory and practice /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Dose-finding designs for early-phase cancer clinical trials/ by Takashi Daimon, Akihiro Hirakawa, Shigeyuki Matsui.
Reminder of title:	a brief guidebook to theory and practice /
Author:	Daimon, Takashi.
other author:	Hirakawa, Akihiro.
Published:	Tokyo :Springer Japan : : 2019.,
Description:	xv, 133 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Antineoplastic agents. -
Online resource:	https://doi.org/10.1007/978-4-431-55585-8
ISBN:	9784431555858

Dose-finding designs for early-phase cancer clinical trials = a brief guidebook to theory and practice /
Daimon, Takashi.

Dose-finding designs for early-phase cancer clinical trialsa brief guidebook to theory and practice /[electronic resource] :by Takashi Daimon, Akihiro Hirakawa, Shigeyuki Matsui. - Tokyo :Springer Japan :2019. - xv, 133 p. :ill., digital ;24 cm. - JSS research series in statistics,2364-0057. - JSS research series in statistics..

1. Introduction -- 2. Dose Finding in Early Phase Clinical Trials -- 3. Rule -- Based Designs -- 4. Continual Reassessment Method Designs -- 5. Escalation with Overdose Control Designs -- 6. Decision -- Theoretic Designs -- 7. Complex Designs.

This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.

ISBN: 9784431555858

Standard No.: 10.1007/978-4-431-55585-8doiSubjects--Topical Terms:

581036
Antineoplastic agents.

LC Class. No.: RC271.C5 / D356 2019

Dewey Class. No.: 615.798

Dose-finding designs for early-phase cancer clinical trials = a brief guidebook to theory and practice /
LDR:02688nam a2200349 a 4500 001 940616
003 DE-He213
005 20191031165717.0
006 m d
007 cr nn 008maaau
008 200417s2019 ja s 0 eng d
020 $a 9784431555858 $q (electronic bk.)
020 $a 9784431555841 $q (paper)
024 7 $a 10.1007/978-4-431-55585-8 $2 doi
035 $a 978-4-431-55585-8
040 $a GP $c GP
041 0 $a eng
050 4 $a RC271.C5 $b D356 2019
072 7 $a PBT $2 bicssc
072 7 $a MED090000 $2 bisacsh
072 7 $a PBT $2 thema
072 7 $a MBNS $2 thema
082 0 4 $a 615.798 $2 23
090 $a RC271.C5 $b D133 2019
100 1 $a Daimon, Takashi. $3 1227385
245 1 0 $a Dose-finding designs for early-phase cancer clinical trials $h [electronic resource] : $b a brief guidebook to theory and practice / $c by Takashi Daimon, Akihiro Hirakawa, Shigeyuki Matsui.
260 $a Tokyo : $c 2019. $b Springer Japan : $b Imprint: Springer,
300 $a xv, 133 p. : $b ill., digital ; $c 24 cm.
490 1 $a JSS research series in statistics, $x 2364-0057
505 0 $a 1. Introduction -- 2. Dose Finding in Early Phase Clinical Trials -- 3. Rule -- Based Designs -- 4. Continual Reassessment Method Designs -- 5. Escalation with Overdose Control Designs -- 6. Decision -- Theoretic Designs -- 7. Complex Designs.
520 $a This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.
650 0 $a Antineoplastic agents. $3 581036
650 0 $a Cancer $x Chemotherapy. $3 645264
650 0 $a Drugs $x Dosage forms. $3 582281
650 1 4 $a Statistics for Life Sciences, Medicine, Health Sciences. $3 670172
650 2 4 $a Statistical Theory and Methods. $3 671396
650 2 4 $a Biostatistics. $3 783654
700 1 $a Hirakawa, Akihiro. $3 1227386
700 1 $a Matsui, Shigeyuki. $3 1172364
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a JSS research series in statistics. $3 1211828
856 4 0 $u https://doi.org/10.1007/978-4-431-55585-8
950 $a Mathematics and Statistics (Springer-11649)