國立虎尾科技大學 |

Increasing the therapeutic ratio of radiotherapy

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Increasing the therapeutic ratio of radiotherapy/ edited by Philip J. Tofilon, Kevin Camphausen.
其他作者:	Tofilon, Philip J.
出版者:	Cham :Springer International Publishing : : 2017.,
面頁冊數:	viii, 280 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Radiotherapy. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-40854-5
ISBN:	9783319408545

Increasing the therapeutic ratio of radiotherapy
Increasing the therapeutic ratio of radiotherapy[electronic resource] /edited by Philip J. Tofilon, Kevin Camphausen. - Cham :Springer International Publishing :2017. - viii, 280 p. :ill., digital ;24 cm. - Cancer drug discovery and development,2196-9906. - Cancer drug discovery and development..

Part 1. Molecular Targets -- 1. Improving the therapeutic ratio of radiotherapy by targeting the DNA Damage Response -- 2. Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity -- 3. Histone Deacetylase Inhibitors and Tumor Radiosensitization -- 4. Radioprotection as a Method to Enhance the Therapeutic Ratio of Radiotherapy -- Part 2. Microenvironment -- 5. Application of Functional Molecular Imaging in Radiation Oncology -- 6. Remodeling the Irradiated Tumor Microenvironment: The 5th R of Radiobiology? -- 7. Combining Radiotherapy and Immunotherapy: Emerging Preclinical Observations of Lymphocyte Costimulatory and Inhibitory Receptor Modulation -- Part 3. Clinical -- 8. Stereotactic Body Radiation Therapy (SBRT) or Alternative Fractionation Schedules -- 9. Novel Imaging for Treatment Planning or Tumor Response -- 10. Increasing the Therapeutic Efficacy of Radiotherapy Using Nanoparticles -- Index.

Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection) Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.

ISBN: 9783319408545

Standard No.: 10.1007/978-3-319-40854-5doiSubjects--Topical Terms:

593952
Radiotherapy.

LC Class. No.: RM847

Dewey Class. No.: 615.842

Increasing the therapeutic ratio of radiotherapy
LDR:03611nam a2200325 a 4500 001 957387
003 DE-He213
005 20161121063640.0
006 m d
007 cr nn 008maaau
008 201118s2017 gw s 0 eng d
020 $a 9783319408545 $q (electronic bk.)
020 $a 9783319408521 $q (paper)
024 7 $a 10.1007/978-3-319-40854-5 $2 doi
035 $a 978-3-319-40854-5
040 $a GP $c GP
041 0 $a eng
050 4 $a RM847
072 7 $a MJCL $2 bicssc
072 7 $a MED062000 $2 bisacsh
082 0 4 $a 615.842 $2 23
090 $a RM847 $b .I37 2017
245 0 0 $a Increasing the therapeutic ratio of radiotherapy $h [electronic resource] / $c edited by Philip J. Tofilon, Kevin Camphausen.
260 $a Cham : $c 2017. $b Springer International Publishing : $b Imprint: Humana Press,
300 $a viii, 280 p. : $b ill., digital ; $c 24 cm.
490 1 $a Cancer drug discovery and development, $x 2196-9906
505 0 $a Part 1. Molecular Targets -- 1. Improving the therapeutic ratio of radiotherapy by targeting the DNA Damage Response -- 2. Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity -- 3. Histone Deacetylase Inhibitors and Tumor Radiosensitization -- 4. Radioprotection as a Method to Enhance the Therapeutic Ratio of Radiotherapy -- Part 2. Microenvironment -- 5. Application of Functional Molecular Imaging in Radiation Oncology -- 6. Remodeling the Irradiated Tumor Microenvironment: The 5th R of Radiobiology? -- 7. Combining Radiotherapy and Immunotherapy: Emerging Preclinical Observations of Lymphocyte Costimulatory and Inhibitory Receptor Modulation -- Part 3. Clinical -- 8. Stereotactic Body Radiation Therapy (SBRT) or Alternative Fractionation Schedules -- 9. Novel Imaging for Treatment Planning or Tumor Response -- 10. Increasing the Therapeutic Efficacy of Radiotherapy Using Nanoparticles -- Index.
520 $a Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection) Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.
650 0 $a Radiotherapy. $3 593952
650 1 4 $a Biomedicine. $3 593880
650 2 4 $a Cancer Research. $3 668358
650 2 4 $a Drug Resistance. $3 782695
700 1 $a Tofilon, Philip J. $3 1248948
700 1 $a Camphausen, Kevin. $3 1248949
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a Cancer drug discovery and development. $3 887663
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-40854-5
950 $a Medicine (Springer-11650)