國立虎尾科技大學 |

Histone Recognition

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Histone Recognition/ edited by Ming-Ming Zhou.
其他作者:	Zhou, Ming-Ming.
面頁冊數:	VIII, 282 p. 69 illus., 51 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Gene expression. -
電子資源:	https://doi.org/10.1007/978-3-319-18102-8
ISBN:	9783319181028

Histone Recognition
Histone Recognition[electronic resource] /edited by Ming-Ming Zhou. - 1st ed. 2015. - VIII, 282 p. 69 illus., 51 illus. in color.online resource.

The Bromodomain as the Acetyl-Lysine Binding Domain in Gene Transcription -- PHD Fingers as Histone Readers -- Methyl-Lysine Recognition by the Royal Family Modules: Chromo, Tudor, MBT, Chromo Barrel, and PWWP Domains -- Histone Recognition by WD40 Proteins -- Methyl-Lys Recognition by Ankyrin Repeat Proteins -- Methyl-Arginine Recognition by Tudor Domains -- Histone Recognition by Tandem Modules and Modulation by Multiple PTMs -- Genome-Wide Profiling of Molecular Recognition of Histone PTMs -- BET Bromodomain Inhibition as a Therapeutic Approach in Hematological Malignancies -- Anti-Inflammatory Effects of BET Protein Inhibition Through Modulation of Gene Transcription -- Activating Latent HIV by Inhibiting Bromodomain Proteins -- Small Molecule Modulation of Methyl-Lysine Mediated Interactions.

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

ISBN: 9783319181028

Standard No.: 10.1007/978-3-319-18102-8doiSubjects--Topical Terms:

581931
Gene expression.

LC Class. No.: QP110.G45

Dewey Class. No.: 611.01816

Histone Recognition
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520 $a This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.
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