國立虎尾科技大學 |

Fundamentals of Neurodegeneration and Protein Misfolding Disorders

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Fundamentals of Neurodegeneration and Protein Misfolding Disorders/ by Martin Beckerman.
Author:	Beckerman, Martin.
Description:	XXII, 378 p. 122 illus., 103 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Neurosciences. -
Online resource:	https://doi.org/10.1007/978-3-319-22117-5
ISBN:	9783319221175

Fundamentals of Neurodegeneration and Protein Misfolding Disorders
Beckerman, Martin.

Fundamentals of Neurodegeneration and Protein Misfolding Disorders[electronic resource] /by Martin Beckerman. - 1st ed. 2015. - XXII, 378 p. 122 illus., 103 illus. in color.online resource. - Biological and Medical Physics, Biomedical Engineering,1618-7210. - Biological and Medical Physics, Biomedical Engineering,.

Introduction -- Protein Folding, Part I: Basic Principles -- Protein Folding, Part II: Energy Landscapes and Protein Dynamics -- Protein Misfolding and Aggregation -- Protein Quality Control, Part I: Molecular Chaperones and the Ubiquitin-Proteasome System -- Protein Quality Control, Part II: Autophagy and Aging -- Prion Diseases -- Alzheimer’s Disease -- Parkinson’s Disease -- Huntington’s Disease and other Unstable Repeat Disorders -- Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.

This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.

ISBN: 9783319221175

Standard No.: 10.1007/978-3-319-22117-5doiSubjects--Topical Terms:

593561
Neurosciences.

LC Class. No.: RC321-580

Dewey Class. No.: 612.8

Fundamentals of Neurodegeneration and Protein Misfolding Disorders
LDR:03821nam a22004095i 4500 001 961112
003 DE-He213
005 20200702141154.0
007 cr nn 008mamaa
008 201211s2015 gw | s |||| 0|eng d
020 $a 9783319221175 $9 978-3-319-22117-5
024 7 $a 10.1007/978-3-319-22117-5 $2 doi
035 $a 978-3-319-22117-5
050 4 $a RC321-580
072 7 $a PSAN $2 bicssc
072 7 $a MED057000 $2 bisacsh
072 7 $a PSAN $2 thema
082 0 4 $a 612.8 $2 23
100 1 $a Beckerman, Martin. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 672698
245 1 0 $a Fundamentals of Neurodegeneration and Protein Misfolding Disorders $h [electronic resource] / $c by Martin Beckerman.
250 $a 1st ed. 2015.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a XXII, 378 p. 122 illus., 103 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Biological and Medical Physics, Biomedical Engineering, $x 1618-7210
505 0 $a Introduction -- Protein Folding, Part I: Basic Principles -- Protein Folding, Part II: Energy Landscapes and Protein Dynamics -- Protein Misfolding and Aggregation -- Protein Quality Control, Part I: Molecular Chaperones and the Ubiquitin-Proteasome System -- Protein Quality Control, Part II: Autophagy and Aging -- Prion Diseases -- Alzheimer’s Disease -- Parkinson’s Disease -- Huntington’s Disease and other Unstable Repeat Disorders -- Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.
520 $a This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
650 0 $a Neurosciences. $3 593561
650 0 $a Biophysics. $3 581576
650 0 $a Biological physics. $3 1253579
650 0 $a Proteins . $3 1253493
650 0 $a Biomedical engineering. $3 588770
650 0 $a Neurology . $3 1253459
650 0 $a Medicinal chemistry. $3 1253747
650 2 4 $a Biological and Medical Physics, Biophysics. $3 1113305
650 2 4 $a Protein Science. $3 782127
650 2 4 $a Biomedical Engineering and Bioengineering. $3 1211019
650 2 4 $a Neurology. $3 593894
650 2 4 $a Medicinal Chemistry. $3 668872
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783319221168
776 0 8 $i Printed edition: $z 9783319221182
776 0 8 $i Printed edition: $z 9783319342849
830 0 $a Biological and Medical Physics, Biomedical Engineering, $x 1618-7210 $3 1255349
856 4 0 $u https://doi.org/10.1007/978-3-319-22117-5
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)