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Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine/ edited by Christophe Le Tourneau, Maud Kamal.
other author:	Le Tourneau, Christophe.
Description:	X, 144 p. 100 illus., 50 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Oncology . -
Online resource:	https://doi.org/10.1007/978-3-319-22189-2
ISBN:	9783319221892

Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine
Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine[electronic resource] /edited by Christophe Le Tourneau, Maud Kamal. - 1st ed. 2015. - X, 144 p. 100 illus., 50 illus. in color.online resource.

Introduction: Rationale for Precision Medicine Clinical Trials.- The Key Role of Pathology in the Context of Precision Medicine Trials -- Basis for Molecular Genetics in Cancer -- Microarrays Based Molecular Profiling to Identify Genomic Alterations -- High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential -- Bioinformatics for Precision Medicine in Oncology -- Assessment of Biomarkers’ Predictive Value of Efficacy -- Designs for Evaluating Precision Medicine Trials -- Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials.

This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice. It also covers the key role of pathology in the validation of molecular results and the complex assessment of predictive biomarkers. The different topics covered are supplemented by unique concrete examples based on the SHIVA trial. The authors are all members of the French Curie Institute, one of the world’s foremost cancer research institutions.

ISBN: 9783319221892

Standard No.: 10.1007/978-3-319-22189-2doiSubjects--Topical Terms:

1253469
Oncology .

LC Class. No.: RC254-282

Dewey Class. No.: 616.994

Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine
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