國立虎尾科技大學 |

Presynaptic Terminals

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Presynaptic Terminals/ edited by Sumiko Mochida.
其他作者:	Mochida, Sumiko.
面頁冊數:	XIV, 365 p. 35 illus., 33 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Neurochemistry. -
電子資源:	https://doi.org/10.1007/978-4-431-55166-9
ISBN:	9784431551669

Presynaptic Terminals
Presynaptic Terminals[electronic resource] /edited by Sumiko Mochida. - 1st ed. 2015. - XIV, 365 p. 35 illus., 33 illus. in color.online resource.

Preface -- Part 1 Overview -- 1 Overview: Presynaptic Terminal Proteins Orchestrate Stepwise Synaptic Vesicle Phases (Sumiko Mochida) -- Part 2 Presynaptic Active Zone Proteins -- 2 Active Zone Assembly (Thomas Dresbach) -- 3 Network of Protein-Protein Interaction at the Presynaptic Active Zone (Toshihisa Ohtsuka) -- Part 3 Synaptic Vesicle Fusion.- 4 Fusion Machinery: SNARE Protein Complex (Ira Milosevic and Jakob B. Sørensen).- 5 Roles of Tomosyn in Neurotransmitter Release (Yasunori Yamamoto and Toshiaki Sakisaka).- 6 Regulation of SNAREs: Complexin (Hiroshi Tokumaru).- 7 The Synaptic Vesicle V-ATPase: A Regulatory Link Between Loading and Fusion? (Oussama El Far and Michael Seager).- 8 Ca2+ Sensors: Synaptotagmins (Tei-ichi Nishiki, Kentaro Kuroki, Toshio Masumoto, and Hideki Matsui).- 9 Regulation of Active Zone Ca2+ Channels (Karina Leal and Sumiko Mochida) -- Part 4 Synaptic Vesicle Endocytosis -- 10 Endocytic Machinery at the Neuronal Synapse (Ira Milosevic) -- 11 Dynamin is a Key Molecule to Decode Action Potential Firing (Shota Tanifuji and Sumiko Mochida) -- Part 5 Synaptic Vesicle Refilling and Storage -- 12 Transport of Amino Acid Neurotransmitters Into Synaptic Vesicles (Shigeo Takamori) -- 13 Synapsins and Synaptic Vesicle Storage (Fabrizia C. Guarnieri, Fabio Benfenati, and Flavia Valtorta) -- Part 6 Synaptic Vesicle Pools -- 14 Synaptic Vesicle Pools: Classical and Emerging Roles (Sven Truckenbrodt and Silvio O. Rizzoli) -- BM Index.

This book brings together leading international experts to discuss recent advances in functional studies on key proteins and protein complexes involved in each synaptic vesicle phase. These include proteins that control the final step of neurotransmitter release, in response to a neural signal, and the first step of vesicle endocytosis, which helps maintain stable neurotransmitter release in response to unceasing neural signals arriving at presynaptic terminals. Neural networks transmit input and output signals of action potentials using chemical synapses. The strength of the signal from one to another neuron can be tuned by the neural signal itself as it induces Ca2+ entry and by other neurons’ signals that modify Ca2+ entry through voltage-gated Ca2+ channels at the active zone, where chemical neurotransmitters are released from synaptic vesicles via exocytosis. Synaptic vesicles are docked and primed at the active zone prior to exocytosis and are endocytosed after exocytosis for reuse at a small presynaptic terminal. Recycled vesicles are refilled with transmitters and stored for a future round of exocytosis. Thus, synaptic vesicles in presynaptic terminals go through various phases. Each vesicle phase is well orchestrated by numerous proteins and advance step-by-step with neural activities. The fine regulations of synaptic vesicle phases by numerous proteins is an exciting subject, and systematic, well-organized explanations in this book will help the reader easily learn about complicated molecular mechanisms in presynaptic terminals.

ISBN: 9784431551669

Standard No.: 10.1007/978-4-431-55166-9doiSubjects--Topical Terms:

581832
Neurochemistry.

LC Class. No.: QP356.3

Dewey Class. No.: 612.8042

Presynaptic Terminals
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