國立虎尾科技大學 |

Protein Modifications in Pathogenic Dysregulation of Signaling

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Protein Modifications in Pathogenic Dysregulation of Signaling/ edited by Jun-ichiro Inoue, Mutsuhiro Takekawa.
其他作者:	Inoue, Jun-ichiro.
面頁冊數:	IX, 348 p. 86 illus., 46 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Proteins . -
電子資源:	https://doi.org/10.1007/978-4-431-55561-2
ISBN:	9784431555612

Protein Modifications in Pathogenic Dysregulation of Signaling
Protein Modifications in Pathogenic Dysregulation of Signaling[electronic resource] /edited by Jun-ichiro Inoue, Mutsuhiro Takekawa. - 1st ed. 2015. - IX, 348 p. 86 illus., 46 illus. in color.online resource.

Preface -- Part I Novel Analytical Procedures for Signal Transduction -- 1 Phosphoproteomics-based Network Analysis of Cancer Cell Signaling Systems (Hiroko Kozuka-Hata and Masaaki Oyama) -- 2 Phos-tag-based Affinity Chromatography Techniques for Enrichment of the Phosphoproteome (Eiji Kinoshita, Emiko Kinoshita-Kikuta, and Tohru Koike) -- 3 Visualization of Intracellular Signaling with Fluorescence Resonance Energy Transfer-based Biosensors (Kazuhiro Aoki) -- 4 Technology of Wheat Cell-free Based Protein Array for Biochemical Analyses of Protein Kinases and Ubiquitin E3 Ligases (Hirotaka Takahashi, Keiichirou Nemoto, Ramadan Abdelaziz, Atsushi Uematsu, and Tatsuya Sawasaki) -- Part II Mathematical Simulation of Signal Transduction -- 5 Potential Roles of Spatial Parameters in the Regulation of NF-κB Oscillations, as Revealed by Computer Simulations (Daisuke Ohshima, Jun-ichiro Inoue, and Kazuhisa Ichikawa) -- 6 Stochastic Simulation of Stress Granules (Daisuke Ohshima, Kyoko Arimoto-Matsuzaki, Taichiro Tomida, Mutsuhiro Takekawa, and Kazuhisa Ichikawa) -- 7 Temporal Coding of Insulin Signaling (Hiroyuki Kubota and Shinya Kuroda) -- Part III Structural Analysis of Signal Transduction -- 8 Structural Biology of Protein Post-transcriptional Modifications and Cellular Signaling (Kazuki Kato, Hiroshi Nishimasu, Ryohei Ishii, Osamu Nureki, and Ryuichiro Ishitani) -- 9 Structural Basis for the Signal Initiation by TNF and TNFR (Teruya Nakamura, Yohei Mukai, Yasuo Tsutsumi, and Yuriko Yamagata) -- 10 Regulation of NF-κB Pathway by Linkage-specific Ubiquitin-binding Domains (Yusuke Sato) -- Part IV Regulation of Signal Transduction by Post-translational Modifications and Its Pathogenic Dysregulation -- 11 NF-κB Signaling and Lymphoid Malignancies (Shoji Yamaoka) -- 12 Ubiquitination-mediated NF-κB Regulation in Inflammatory Response (Fuminori Tokunaga) -- 13 NF-κB Signaling in Osteoclastogenesis (Yuu Taguchi, Jin Gohda, and Jun-ichiro Inoue) -- 14 Mitogen-activated Protein Kinase Signaling and Cancer (Mutsuhiro Takekawa and Yuji Kubota) -- 15 Critical Roles of the AKT Substrate Girdin in Disease Initiation and Progression (Atsushi Enomoto, Liang Weng, and Masahide Takahashi) -- 16 Protein Modifications Pace the Circadian Oscillation of Biological Clocks (Hikari Yoshitane and Yoshitaka Fukada) -- 17 Keap1-Nrf2 Regulatory System and Cancer (Keiko Taguchi and Masayuki Yamamoto) -- 18 Actin Filament Formation in Myofibrils and Cell Protrusions Regulated by Signal Transduction (Takeshi Endo and Kazunori Takano) -- 19 Molecular Signaling and its Pathogenic Alterations in Neuromuscular Junction Formation and Maintenance (Ryo Ueta and Yuji Yamanashi) -- 20 Post-translational Modification of Tcf/Lef: New Insights into the Regulation of Wnt/β-catenin Signaling (Tohru Ishitani) -- BM Index.

This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases.

ISBN: 9784431555612

Standard No.: 10.1007/978-4-431-55561-2doiSubjects--Topical Terms:

1253493
Proteins .

LC Class. No.: QD431-431.7

Dewey Class. No.: 572.6

Protein Modifications in Pathogenic Dysregulation of Signaling
LDR:05852nam a22003975i 4500 001 963223
003 DE-He213
005 20200701143103.0
007 cr nn 008mamaa
008 201211s2015 ja | s |||| 0|eng d
020 $a 9784431555612 $9 978-4-431-55561-2
024 7 $a 10.1007/978-4-431-55561-2 $2 doi
035 $a 978-4-431-55561-2
050 4 $a QD431-431.7
072 7 $a PSBC $2 bicssc
072 7 $a SCI007000 $2 bisacsh
072 7 $a PSB $2 thema
082 0 4 $a 572.6 $2 23
245 1 0 $a Protein Modifications in Pathogenic Dysregulation of Signaling $h [electronic resource] / $c edited by Jun-ichiro Inoue, Mutsuhiro Takekawa.
250 $a 1st ed. 2015.
264 1 $a Tokyo : $b Springer Japan : $b Imprint: Springer, $c 2015.
300 $a IX, 348 p. 86 illus., 46 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a Preface -- Part I Novel Analytical Procedures for Signal Transduction -- 1 Phosphoproteomics-based Network Analysis of Cancer Cell Signaling Systems (Hiroko Kozuka-Hata and Masaaki Oyama) -- 2 Phos-tag-based Affinity Chromatography Techniques for Enrichment of the Phosphoproteome (Eiji Kinoshita, Emiko Kinoshita-Kikuta, and Tohru Koike) -- 3 Visualization of Intracellular Signaling with Fluorescence Resonance Energy Transfer-based Biosensors (Kazuhiro Aoki) -- 4 Technology of Wheat Cell-free Based Protein Array for Biochemical Analyses of Protein Kinases and Ubiquitin E3 Ligases (Hirotaka Takahashi, Keiichirou Nemoto, Ramadan Abdelaziz, Atsushi Uematsu, and Tatsuya Sawasaki) -- Part II Mathematical Simulation of Signal Transduction -- 5 Potential Roles of Spatial Parameters in the Regulation of NF-κB Oscillations, as Revealed by Computer Simulations (Daisuke Ohshima, Jun-ichiro Inoue, and Kazuhisa Ichikawa) -- 6 Stochastic Simulation of Stress Granules (Daisuke Ohshima, Kyoko Arimoto-Matsuzaki, Taichiro Tomida, Mutsuhiro Takekawa, and Kazuhisa Ichikawa) -- 7 Temporal Coding of Insulin Signaling (Hiroyuki Kubota and Shinya Kuroda) -- Part III Structural Analysis of Signal Transduction -- 8 Structural Biology of Protein Post-transcriptional Modifications and Cellular Signaling (Kazuki Kato, Hiroshi Nishimasu, Ryohei Ishii, Osamu Nureki, and Ryuichiro Ishitani) -- 9 Structural Basis for the Signal Initiation by TNF and TNFR (Teruya Nakamura, Yohei Mukai, Yasuo Tsutsumi, and Yuriko Yamagata) -- 10 Regulation of NF-κB Pathway by Linkage-specific Ubiquitin-binding Domains (Yusuke Sato) -- Part IV Regulation of Signal Transduction by Post-translational Modifications and Its Pathogenic Dysregulation -- 11 NF-κB Signaling and Lymphoid Malignancies (Shoji Yamaoka) -- 12 Ubiquitination-mediated NF-κB Regulation in Inflammatory Response (Fuminori Tokunaga) -- 13 NF-κB Signaling in Osteoclastogenesis (Yuu Taguchi, Jin Gohda, and Jun-ichiro Inoue) -- 14 Mitogen-activated Protein Kinase Signaling and Cancer (Mutsuhiro Takekawa and Yuji Kubota) -- 15 Critical Roles of the AKT Substrate Girdin in Disease Initiation and Progression (Atsushi Enomoto, Liang Weng, and Masahide Takahashi) -- 16 Protein Modifications Pace the Circadian Oscillation of Biological Clocks (Hikari Yoshitane and Yoshitaka Fukada) -- 17 Keap1-Nrf2 Regulatory System and Cancer (Keiko Taguchi and Masayuki Yamamoto) -- 18 Actin Filament Formation in Myofibrils and Cell Protrusions Regulated by Signal Transduction (Takeshi Endo and Kazunori Takano) -- 19 Molecular Signaling and its Pathogenic Alterations in Neuromuscular Junction Formation and Maintenance (Ryo Ueta and Yuji Yamanashi) -- 20 Post-translational Modification of Tcf/Lef: New Insights into the Regulation of Wnt/β-catenin Signaling (Tohru Ishitani) -- BM Index.
520 $a This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases.
650 0 $a Proteins . $3 1253493
650 0 $a Cell biology. $3 1253486
650 0 $a Cancer research. $3 1253664
650 1 4 $a Protein Science. $3 782127
650 2 4 $a Cell Biology. $3 593889
650 2 4 $a Cancer Research. $3 668358
700 1 $a Inoue, Jun-ichiro. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1068982
700 1 $a Takekawa, Mutsuhiro. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1068983
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9784431555629
776 0 8 $i Printed edition: $z 9784431555605
776 0 8 $i Printed edition: $z 9784431562535
856 4 0 $u https://doi.org/10.1007/978-4-431-55561-2
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)