國立虎尾科技大學 |

The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy/ by Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horst-Werner Korf.
作者:	Rüb, Udo.
其他作者:	Vonsattel, Jean Paul G.
面頁冊數:	XIV, 146 p. 50 illus., 47 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Neurosciences. -
電子資源:	https://doi.org/10.1007/978-3-319-19285-7
ISBN:	9783319192857

The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy
Rüb, Udo.

The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy[electronic resource] /by Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horst-Werner Korf. - 1st ed. 2015. - XIV, 146 p. 50 illus., 47 illus. in color.online resource. - Advances in Anatomy, Embryology and Cell Biology,2170301-5556 ;. - Advances in Anatomy, Embryology and Cell Biology,217.

1. Introduction -- 2. The neuropathological grading of Huntington disease -- 3. The cerebral cortex in Huntington´s disease -- 4. Degeneration of select motor and limbic nuclei of the thalamus in Huntington’s disease -- 5. Consistent and widespread degeneration of the cerebellum in Huntington’s disease -- 6. Elucidation of the role of the premotor oculomotor brainstem nuclei in the pathogenesis of oculomotor dysfunctions in Huntington’s disease -- 7. Widespread brainstem neurodegeneration in Huntington’s disease -- 8. Intraneuronal transport and defense mechanisms with possible pathogenetic relevance in Huntington’s disease -- 9. The disease protein huntingtin and neuronal protein aggregations in Huntington’s disease -- 10. Pathological nerve cell alterations in Huntington’s disease (HD) and their possible role for the demise of nerve cells -- 11. Conclusions and outlook.

This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.

ISBN: 9783319192857

Standard No.: 10.1007/978-3-319-19285-7doiSubjects--Topical Terms:

593561
Neurosciences.

LC Class. No.: RC321-580

Dewey Class. No.: 612.8

The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy
LDR:03445nam a22003975i 4500 001 965828
003 DE-He213
005 20200702065637.0
007 cr nn 008mamaa
008 201211s2015 gw | s |||| 0|eng d
020 $a 9783319192857 $9 978-3-319-19285-7
024 7 $a 10.1007/978-3-319-19285-7 $2 doi
035 $a 978-3-319-19285-7
050 4 $a RC321-580
072 7 $a PSAN $2 bicssc
072 7 $a MED057000 $2 bisacsh
072 7 $a PSAN $2 thema
082 0 4 $a 612.8 $2 23
100 1 $a Rüb, Udo. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1261470
245 1 4 $a The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy $h [electronic resource] / $c by Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horst-Werner Korf.
250 $a 1st ed. 2015.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a XIV, 146 p. 50 illus., 47 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Advances in Anatomy, Embryology and Cell Biology, $x 0301-5556 ; $v 217
505 0 $a 1. Introduction -- 2. The neuropathological grading of Huntington disease -- 3. The cerebral cortex in Huntington´s disease -- 4. Degeneration of select motor and limbic nuclei of the thalamus in Huntington’s disease -- 5. Consistent and widespread degeneration of the cerebellum in Huntington’s disease -- 6. Elucidation of the role of the premotor oculomotor brainstem nuclei in the pathogenesis of oculomotor dysfunctions in Huntington’s disease -- 7. Widespread brainstem neurodegeneration in Huntington’s disease -- 8. Intraneuronal transport and defense mechanisms with possible pathogenetic relevance in Huntington’s disease -- 9. The disease protein huntingtin and neuronal protein aggregations in Huntington’s disease -- 10. Pathological nerve cell alterations in Huntington’s disease (HD) and their possible role for the demise of nerve cells -- 11. Conclusions and outlook.
520 $a This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
650 0 $a Neurosciences. $3 593561
650 0 $a Human genetics. $3 596505
650 0 $a Pathology. $3 668553
650 2 4 $a Human Genetics. $3 593893
700 1 $a Vonsattel, Jean Paul G. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1261471
700 1 $a Heinsen, Helmut. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1261472
700 1 $a Korf, Horst-Werner. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1261473
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783319192864
776 0 8 $i Printed edition: $z 9783319192840
830 0 $a Advances in Anatomy, Embryology and Cell Biology, $x 0301-5556 ; $v 217 $3 1261474
856 4 0 $u https://doi.org/10.1007/978-3-319-19285-7
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)