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Optimized Response-Adaptive Clinical Trials = Sequential Treatment Allocation Based on Markov Decision Problems /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Optimized Response-Adaptive Clinical Trials/ by Thomas Ondra.
Reminder of title:	Sequential Treatment Allocation Based on Markov Decision Problems /
Author:	Ondra, Thomas.
Description:	XV, 102 p. 14 illus.online resource. :
Contained By:	Springer Nature eBook
Subject:	Computer mathematics. -
Online resource:	https://doi.org/10.1007/978-3-658-08344-1
ISBN:	9783658083441

Optimized Response-Adaptive Clinical Trials = Sequential Treatment Allocation Based on Markov Decision Problems /
Ondra, Thomas.

Optimized Response-Adaptive Clinical TrialsSequential Treatment Allocation Based on Markov Decision Problems /[electronic resource] :by Thomas Ondra. - 1st ed. 2015. - XV, 102 p. 14 illus.online resource. - BestMasters,2625-3577. - BestMasters,.

Introduction to Markov Decision Problems and Examples -- Finite and Infinite Horizon Markov Decision Problems -- Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration -- Designing Response Adaptive Clinical Trials with Markov Decision Problems.

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences. Contents Introduction to Markov Decision Problems and Examples Finite and Infinite Horizon Markov Decision Problems Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration Designing Response Adaptive Clinical Trials with Markov Decision Problems Target Groups Researchers and students in the fields of mathematics and statistics Professionals in the pharmaceutical industry< The Author Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna. .

ISBN: 9783658083441

Standard No.: 10.1007/978-3-658-08344-1doiSubjects--Topical Terms:

1199796
Computer mathematics.

LC Class. No.: QA71-90

Dewey Class. No.: 518

Optimized Response-Adaptive Clinical Trials = Sequential Treatment Allocation Based on Markov Decision Problems /
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