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Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells = Mathematical Modeling and Experimental Observations /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells/ by Iman Tavassoly.
Reminder of title:	Mathematical Modeling and Experimental Observations /
Author:	Tavassoly, Iman.
Description:	XXI, 79 p. 47 illus., 1 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Biomaterials. -
Online resource:	https://doi.org/10.1007/978-3-319-14962-2
ISBN:	9783319149622

Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells = Mathematical Modeling and Experimental Observations /
Tavassoly, Iman.

Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer CellsMathematical Modeling and Experimental Observations /[electronic resource] :by Iman Tavassoly. - 1st ed. 2015. - XXI, 79 p. 47 illus., 1 illus. in color.online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053. - Springer Theses, Recognizing Outstanding Ph.D. Research,.

Introduction -- Mathematical Modeling of the Interplay of Autophagy and Apoptosis -- An Experimental Framework to Study the Dynamics of Autophagic Response -- Conclusions -- Source Code.

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

ISBN: 9783319149622

Standard No.: 10.1007/978-3-319-14962-2doiSubjects--Topical Terms:

677000
Biomaterials.

LC Class. No.: R857.M3

Dewey Class. No.: 620.11

Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells = Mathematical Modeling and Experimental Observations /
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