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Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene/ by Amita Kashyap, D. Bujamma, Naresh Babu M.
作者:	Kashyap, Amita.
其他作者:	Bujamma, D.
面頁冊數:	VII, 72 p. 40 illus., 39 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Computational intelligence. -
電子資源:	https://doi.org/10.1007/978-981-4585-08-8
ISBN:	9789814585088

Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene
Kashyap, Amita.

Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene[electronic resource] /by Amita Kashyap, D. Bujamma, Naresh Babu M. - 1st ed. 2015. - VII, 72 p. 40 illus., 39 illus. in color.online resource. - SpringerBriefs in Forensic and Medical Bioinformatics,2196-8845. - SpringerBriefs in Forensic and Medical Bioinformatics,.

Introduction -- Review of Literature -- Materials and Methods (Tools and Databases) -- Flowchart -- Conclusion.-References.

Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

ISBN: 9789814585088

Standard No.: 10.1007/978-981-4585-08-8doiSubjects--Topical Terms:

568984
Computational intelligence.

LC Class. No.: Q342

Dewey Class. No.: 006.3

Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene
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