語系:
繁體中文
English
說明(常見問題)
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Transglutaminases = Multiple Functio...
~
Fesus, Laszlo.
Transglutaminases = Multiple Functional Modifiers and Targets for New Drug Discovery /
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Transglutaminases/ edited by Kiyotaka Hitomi, Soichi Kojima, Laszlo Fesus.
其他題名:
Multiple Functional Modifiers and Targets for New Drug Discovery /
其他作者:
Hitomi, Kiyotaka.
面頁冊數:
VIII, 391 p. 85 illus., 37 illus. in color.online resource. :
Contained By:
Springer Nature eBook
標題:
Pharmaceutical technology. -
電子資源:
https://doi.org/10.1007/978-4-431-55825-5
ISBN:
9784431558255
Transglutaminases = Multiple Functional Modifiers and Targets for New Drug Discovery /
Transglutaminases
Multiple Functional Modifiers and Targets for New Drug Discovery /[electronic resource] :edited by Kiyotaka Hitomi, Soichi Kojima, Laszlo Fesus. - 1st ed. 2015. - VIII, 391 p. 85 illus., 37 illus. in color.online resource.
1 Structure of Transglutaminases. Unique Features Serve Diverse Functions -- 2 Control of Tg Functions Depending on their Localization -- 3 Preferred Substrate Structure of Transglutaminases -- 4 Insights into Transglutaminase 2 Function Gained from Genetically-Modified Animal Models -- 5 Tranglutaminase in Invertebrates -- 6 Formation of Integrin-Binding Site on Polymer of Transglutamination -- 7 Transglutaminase 2-Mediated Gene Regulation -- 8 The Role of Transglutaminase Type 2 in the Regulation of Autophagy -- 9 Transglutaminase 2 and Celiac Disease -- 10 Transglutaminase ii and Metastasis: How Hot is the Link?- 11 Transglutaminases: Expression in Kidney and Relation to Kidney Fibrosis -- 12 Transglutaminases in Bone Formation and Bone Matrix Stabilization -- 13 Transglutaminases and Neurological Diseases -- 14 Transglutaminase; Mechanism by Oxidative Stress -- 15 Blood Coagulation Factor Xiii : A Multifunctional Transglutaminase -- 16 Inhibition of Transglutaminase -- 17 Substrate Engineering of Microbial Transglutaminase for Site-Specific Protein Modification and Bioconjugation.
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although several of their essential physiological roles have been revealed, many unknown and so far not fully understood functions have remained. In humans, there are eight active isozymes having distinct tissue and subcellular distribution patterns with different substrates and physiological roles. Accordingly, aberrant regulation of the enzyme reactions or expression may lead to or has been implicated in various pathologies including neurodegeneration, fibrosis, cancer, inflammation, celiac disease, and hemostasis disorders.To provide those who are new to the field with basic knowledge and recent information on transglutaminase structures and reactions, the mechanism by which transglutaminases modify substrate proteins and their contributions to multiple biological phenomena as well as disease phenotypes, the publication of the present transglutaminase book was planned, to consist of review articles by 17 expert investigators working in this exciting area of research. The book contains detailed information related to several transglutaminases from aspects in chemical and cellular biology, medical sciences, and biotechnology that will also supply starting points for drug discovery. Although many prominent findings have been published in recent years, this type of comprehensive review book has been missing in the scientific literature. This volume will be useful for investigators who either currently work on or will start addressing transglutaminase-related research, and beyond that, for a broad audience in the scientific community. .
ISBN: 9784431558255
Standard No.: 10.1007/978-4-431-55825-5doiSubjects--Topical Terms:
557391
Pharmaceutical technology.
LC Class. No.: RS380
Dewey Class. No.: 615.19
Transglutaminases = Multiple Functional Modifiers and Targets for New Drug Discovery /
LDR
:04488nam a22004095i 4500
001
969553
003
DE-He213
005
20200630170316.0
007
cr nn 008mamaa
008
201211s2015 ja | s |||| 0|eng d
020
$a
9784431558255
$9
978-4-431-55825-5
024
7
$a
10.1007/978-4-431-55825-5
$2
doi
035
$a
978-4-431-55825-5
050
4
$a
RS380
050
4
$a
RS190-210
072
7
$a
TDCW
$2
bicssc
072
7
$a
MED072000
$2
bisacsh
072
7
$a
TDC
$2
thema
082
0 4
$a
615.19
$2
23
245
1 0
$a
Transglutaminases
$h
[electronic resource] :
$b
Multiple Functional Modifiers and Targets for New Drug Discovery /
$c
edited by Kiyotaka Hitomi, Soichi Kojima, Laszlo Fesus.
250
$a
1st ed. 2015.
264
1
$a
Tokyo :
$b
Springer Japan :
$b
Imprint: Springer,
$c
2015.
300
$a
VIII, 391 p. 85 illus., 37 illus. in color.
$b
online resource.
336
$a
text
$b
txt
$2
rdacontent
337
$a
computer
$b
c
$2
rdamedia
338
$a
online resource
$b
cr
$2
rdacarrier
347
$a
text file
$b
PDF
$2
rda
505
0
$a
1 Structure of Transglutaminases. Unique Features Serve Diverse Functions -- 2 Control of Tg Functions Depending on their Localization -- 3 Preferred Substrate Structure of Transglutaminases -- 4 Insights into Transglutaminase 2 Function Gained from Genetically-Modified Animal Models -- 5 Tranglutaminase in Invertebrates -- 6 Formation of Integrin-Binding Site on Polymer of Transglutamination -- 7 Transglutaminase 2-Mediated Gene Regulation -- 8 The Role of Transglutaminase Type 2 in the Regulation of Autophagy -- 9 Transglutaminase 2 and Celiac Disease -- 10 Transglutaminase ii and Metastasis: How Hot is the Link?- 11 Transglutaminases: Expression in Kidney and Relation to Kidney Fibrosis -- 12 Transglutaminases in Bone Formation and Bone Matrix Stabilization -- 13 Transglutaminases and Neurological Diseases -- 14 Transglutaminase; Mechanism by Oxidative Stress -- 15 Blood Coagulation Factor Xiii : A Multifunctional Transglutaminase -- 16 Inhibition of Transglutaminase -- 17 Substrate Engineering of Microbial Transglutaminase for Site-Specific Protein Modification and Bioconjugation.
520
$a
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although several of their essential physiological roles have been revealed, many unknown and so far not fully understood functions have remained. In humans, there are eight active isozymes having distinct tissue and subcellular distribution patterns with different substrates and physiological roles. Accordingly, aberrant regulation of the enzyme reactions or expression may lead to or has been implicated in various pathologies including neurodegeneration, fibrosis, cancer, inflammation, celiac disease, and hemostasis disorders.To provide those who are new to the field with basic knowledge and recent information on transglutaminase structures and reactions, the mechanism by which transglutaminases modify substrate proteins and their contributions to multiple biological phenomena as well as disease phenotypes, the publication of the present transglutaminase book was planned, to consist of review articles by 17 expert investigators working in this exciting area of research. The book contains detailed information related to several transglutaminases from aspects in chemical and cellular biology, medical sciences, and biotechnology that will also supply starting points for drug discovery. Although many prominent findings have been published in recent years, this type of comprehensive review book has been missing in the scientific literature. This volume will be useful for investigators who either currently work on or will start addressing transglutaminase-related research, and beyond that, for a broad audience in the scientific community. .
650
0
$a
Pharmaceutical technology.
$3
557391
650
0
$a
Biochemistry.
$3
582831
650
0
$a
Enzymology.
$3
782178
650
1 4
$a
Pharmaceutical Sciences/Technology.
$3
768561
650
2 4
$a
Animal Biochemistry.
$3
668644
700
1
$a
Hitomi, Kiyotaka.
$4
edt
$4
http://id.loc.gov/vocabulary/relators/edt
$3
1070672
700
1
$a
Kojima, Soichi.
$4
edt
$4
http://id.loc.gov/vocabulary/relators/edt
$3
1070673
700
1
$a
Fesus, Laszlo.
$4
edt
$4
http://id.loc.gov/vocabulary/relators/edt
$3
1070674
710
2
$a
SpringerLink (Online service)
$3
593884
773
0
$t
Springer Nature eBook
776
0 8
$i
Printed edition:
$z
9784431558231
776
0 8
$i
Printed edition:
$z
9784431558248
776
0 8
$i
Printed edition:
$z
9784431567035
856
4 0
$u
https://doi.org/10.1007/978-4-431-55825-5
912
$a
ZDB-2-SBL
912
$a
ZDB-2-SXB
950
$a
Biomedical and Life Sciences (SpringerNature-11642)
950
$a
Biomedical and Life Sciences (R0) (SpringerNature-43708)
筆 0 讀者評論
多媒體
評論
新增評論
分享你的心得
Export
取書館別
處理中
...
變更密碼[密碼必須為2種組合(英文和數字)及長度為10碼以上]
登入