國立虎尾科技大學 |

Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds/ by Stacey L. McDonald.
Author:	McDonald, Stacey L.
Description:	XXIII, 144 p. 8 illus.online resource. :
Contained By:	Springer Nature eBook
Subject:	Organometallic chemistry . -
Online resource:	https://doi.org/10.1007/978-3-319-38878-6
ISBN:	9783319388786

Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds
McDonald, Stacey L.

Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds[electronic resource] /by Stacey L. McDonald. - 1st ed. 2016. - XXIII, 144 p. 8 illus.online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053. - Springer Theses, Recognizing Outstanding Ph.D. Research,.

Electrophilic amination for the synthesis of alkyl and aryl amines -- Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates -- Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives -- Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C−H Zincation.

This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. .

ISBN: 9783319388786

Standard No.: 10.1007/978-3-319-38878-6doiSubjects--Topical Terms:

1254952
Organometallic chemistry .

LC Class. No.: QD410-412.5

Dewey Class. No.: 547.05

Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds
LDR:02670nam a22004095i 4500 001 972151
003 DE-He213
005 20200701223729.0
007 cr nn 008mamaa
008 201211s2016 gw | s |||| 0|eng d
020 $a 9783319388786 $9 978-3-319-38878-6
024 7 $a 10.1007/978-3-319-38878-6 $2 doi
035 $a 978-3-319-38878-6
050 4 $a QD410-412.5
072 7 $a PNND $2 bicssc
072 7 $a SCI013040 $2 bisacsh
072 7 $a PNND $2 thema
082 0 4 $a 547.05 $2 23
100 1 $a McDonald, Stacey L. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1112298
245 1 0 $a Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds $h [electronic resource] / $c by Stacey L. McDonald.
250 $a 1st ed. 2016.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a XXIII, 144 p. 8 illus. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Springer Theses, Recognizing Outstanding Ph.D. Research, $x 2190-5053
505 0 $a Electrophilic amination for the synthesis of alkyl and aryl amines -- Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates -- Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives -- Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C−H Zincation.
520 $a This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. .
650 0 $a Organometallic chemistry . $3 1254952
650 0 $a Medicinal chemistry. $3 1253747
650 0 $a Chemical engineering. $3 555952
650 1 4 $a Organometallic Chemistry. $3 674440
650 2 4 $a Medicinal Chemistry. $3 668872
650 2 4 $a Industrial Chemistry/Chemical Engineering. $3 671153
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783319388779
776 0 8 $i Printed edition: $z 9783319388793
776 0 8 $i Printed edition: $z 9783319817675
830 0 $a Springer Theses, Recognizing Outstanding Ph.D. Research, $x 2190-5053 $3 1253569
856 4 0 $u https://doi.org/10.1007/978-3-319-38878-6
912 $a ZDB-2-CMS
912 $a ZDB-2-SXC
950 $a Chemistry and Materials Science (SpringerNature-11644)
950 $a Chemistry and Material Science (R0) (SpringerNature-43709)