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Novel (Trans)dermal Drug Delivery St...
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Hazel, Garvie-Cook.
Novel (Trans)dermal Drug Delivery Strategies = Micro- and Nano-scale Assessments /
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Novel (Trans)dermal Drug Delivery Strategies/ by Garvie-Cook Hazel.
其他題名:
Micro- and Nano-scale Assessments /
作者:
Hazel, Garvie-Cook.
面頁冊數:
XVIII, 114 p. 49 illus., 24 illus. in color.online resource. :
Contained By:
Springer Nature eBook
標題:
Medical physics. -
電子資源:
https://doi.org/10.1007/978-3-319-28901-4
ISBN:
9783319289014
Novel (Trans)dermal Drug Delivery Strategies = Micro- and Nano-scale Assessments /
Hazel, Garvie-Cook.
Novel (Trans)dermal Drug Delivery Strategies
Micro- and Nano-scale Assessments /[electronic resource] :by Garvie-Cook Hazel. - 1st ed. 2016. - XVIII, 114 p. 49 illus., 24 illus. in color.online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053. - Springer Theses, Recognizing Outstanding Ph.D. Research,.
Introduction -- Background -- Methodology -- TEC Plasticization of Topical Polymeric Films -- Lipid Incorporation into Topical Polymeric Films -- Laser Microporation of Skin -- Conclusion.
This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.
ISBN: 9783319289014
Standard No.: 10.1007/978-3-319-28901-4doiSubjects--Topical Terms:
588800
Medical physics.
LC Class. No.: QC474-496.9
Dewey Class. No.: 610.153
Novel (Trans)dermal Drug Delivery Strategies = Micro- and Nano-scale Assessments /
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