國立虎尾科技大學 |

Novel (Trans)dermal Drug Delivery Strategies = Micro- and Nano-scale Assessments /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Novel (Trans)dermal Drug Delivery Strategies/ by Garvie-Cook Hazel.
Reminder of title:	Micro- and Nano-scale Assessments /
Author:	Hazel, Garvie-Cook.
Description:	XVIII, 114 p. 49 illus., 24 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Medical physics. -
Online resource:	https://doi.org/10.1007/978-3-319-28901-4
ISBN:	9783319289014

Novel (Trans)dermal Drug Delivery Strategies = Micro- and Nano-scale Assessments /
Hazel, Garvie-Cook.

Novel (Trans)dermal Drug Delivery StrategiesMicro- and Nano-scale Assessments /[electronic resource] :by Garvie-Cook Hazel. - 1st ed. 2016. - XVIII, 114 p. 49 illus., 24 illus. in color.online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053. - Springer Theses, Recognizing Outstanding Ph.D. Research,.

Introduction -- Background -- Methodology -- TEC Plasticization of Topical Polymeric Films -- Lipid Incorporation into Topical Polymeric Films -- Laser Microporation of Skin -- Conclusion.

This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.

ISBN: 9783319289014

Standard No.: 10.1007/978-3-319-28901-4doiSubjects--Topical Terms:

588800
Medical physics.

LC Class. No.: QC474-496.9

Dewey Class. No.: 610.153

Novel (Trans)dermal Drug Delivery Strategies = Micro- and Nano-scale Assessments /
LDR:02914nam a22004335i 4500 001 974457
003 DE-He213
005 20200630091453.0
007 cr nn 008mamaa
008 201211s2016 gw | s |||| 0|eng d
020 $a 9783319289014 $9 978-3-319-28901-4
024 7 $a 10.1007/978-3-319-28901-4 $2 doi
035 $a 978-3-319-28901-4
050 4 $a QC474-496.9
050 4 $a R895-920
072 7 $a PHVD $2 bicssc
072 7 $a SCI058000 $2 bisacsh
072 7 $a MKSH $2 thema
072 7 $a PNRL $2 thema
082 0 4 $a 610.153 $2 23
100 1 $a Hazel, Garvie-Cook. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1269236
245 1 0 $a Novel (Trans)dermal Drug Delivery Strategies $h [electronic resource] : $b Micro- and Nano-scale Assessments / $c by Garvie-Cook Hazel.
250 $a 1st ed. 2016.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a XVIII, 114 p. 49 illus., 24 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Springer Theses, Recognizing Outstanding Ph.D. Research, $x 2190-5053
505 0 $a Introduction -- Background -- Methodology -- TEC Plasticization of Topical Polymeric Films -- Lipid Incorporation into Topical Polymeric Films -- Laser Microporation of Skin -- Conclusion.
520 $a This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.
650 0 $a Medical physics. $3 588800
650 0 $a Radiation. $3 673044
650 0 $a Biomedical engineering. $3 588770
650 0 $a Polymers . $3 1253577
650 0 $a Nanotechnology. $3 557660
650 1 4 $a Medical and Radiation Physics. $3 784894
650 2 4 $a Biomedical Engineering/Biotechnology. $3 1068811
650 2 4 $a Polymer Sciences. $3 671409
650 2 4 $a Biomedical Engineering and Bioengineering. $3 1211019
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783319289007
776 0 8 $i Printed edition: $z 9783319289021
776 0 8 $i Printed edition: $z 9783319804538
830 0 $a Springer Theses, Recognizing Outstanding Ph.D. Research, $x 2190-5053 $3 1253569
856 4 0 $u https://doi.org/10.1007/978-3-319-28901-4
912 $a ZDB-2-PHA
912 $a ZDB-2-SXP
950 $a Physics and Astronomy (SpringerNature-11651)
950 $a Physics and Astronomy (R0) (SpringerNature-43715)