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Myeloid-Derived Suppressor Cells and Cancer

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Myeloid-Derived Suppressor Cells and Cancer/ by David Escors, James E. Talmadge, Karine Breckpot, Jo A. Van Ginderachter, Grazyna Kochan.
Author:	Escors, David.
other author:	Talmadge, James E.
Description:	IX, 102 p. 8 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Immunology. -
Online resource:	https://doi.org/10.1007/978-3-319-26821-7
ISBN:	9783319268217

Myeloid-Derived Suppressor Cells and Cancer
Escors, David.

Myeloid-Derived Suppressor Cells and Cancer[electronic resource] /by David Escors, James E. Talmadge, Karine Breckpot, Jo A. Van Ginderachter, Grazyna Kochan. - 1st ed. 2016. - IX, 102 p. 8 illus. in color.online resource. - SpringerBriefs in Immunology,2194-2773. - SpringerBriefs in Immunology,.

Controversies in Neoplastic Myeloplasia -- Differentiation of Murine Myeloid-derived Suppressor Cells -- Human MDSCs -- Ex Vivo MDSC Differentiation Models -- Immunoregulatory myeloid cells in the tumor microenvironment -- Signal Transducer and Activation of Transcription 3: A Master Regulator of Myeloid-derived Suppressor Cells -- Future Perspectives.

The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

ISBN: 9783319268217

Standard No.: 10.1007/978-3-319-26821-7doiSubjects--Topical Terms:

592892
Immunology.

LC Class. No.: QR180-189.5

Dewey Class. No.: 616.079

Myeloid-Derived Suppressor Cells and Cancer
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