國立虎尾科技大學 |

Structural Bioinformatics Tools for Drug Design = Extraction of Biologically Relevant Information from Structural Databases /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Structural Bioinformatics Tools for Drug Design/ by Jaroslav Koča, Radka Svobodová Vařeková, Lukáš Pravda, Karel Berka, Stanislav Geidl, David Sehnal, Michal Otyepka.
其他題名:	Extraction of Biologically Relevant Information from Structural Databases /
作者:	Koča, Jaroslav.
其他作者:	Svobodová Vařeková, Radka.
面頁冊數:	XIII, 144 p. 62 illus.online resource. :
Contained By:	Springer Nature eBook
標題:	Biomedical engineering. -
電子資源:	https://doi.org/10.1007/978-3-319-47388-8
ISBN:	9783319473888

Structural Bioinformatics Tools for Drug Design = Extraction of Biologically Relevant Information from Structural Databases /
Koča, Jaroslav.

Structural Bioinformatics Tools for Drug DesignExtraction of Biologically Relevant Information from Structural Databases /[electronic resource] :by Jaroslav Koča, Radka Svobodová Vařeková, Lukáš Pravda, Karel Berka, Stanislav Geidl, David Sehnal, Michal Otyepka. - 1st ed. 2016. - XIII, 144 p. 62 illus.online resource. - SpringerBriefs in Biochemistry and Molecular Biology,2211-9353. - SpringerBriefs in Biochemistry and Molecular Biology,.

1. Introduction -- 2. Biomacromolecular fragments -- 3. Databases -- 4. Detection & Extraction -- a. Biomacromolecular fragments and structural patterns -- b. channels and pores -- 5. Validation -- 6. Characterization -- a. Partial atomic charges -- b. Channel characteristics -- 7. Selected Examples.

A large amount of structural data on biomacromolecules is available and the number of resolved structures is growing rapidly. This implies that we have an increasing opportunity to perform so far unprecedented analyses to obtain crucial biological insight. Biomacromolecular structural fragments such as binding sites or active sites, ligands, channels, pores, secondary structure motifs, etc., become very promising objects for these analyses because such fragments often serve as drug targets or drug templates, or substrate-specific pathways. However, such analyses are very challenging due to their complexity and, consequently, also because they require application of a combination of different software tools. In this book, we describe individual steps necessary for analysis of biomacromolecular fragments and provide a lsit of software tools required to perform such steps. For each step, we also show corresponding web-based tools in detail and provide a few practical examples of their usage.

ISBN: 9783319473888

Standard No.: 10.1007/978-3-319-47388-8doiSubjects--Topical Terms:

588770
Biomedical engineering.

LC Class. No.: R856-R857

Dewey Class. No.: 610.28

Structural Bioinformatics Tools for Drug Design = Extraction of Biologically Relevant Information from Structural Databases /
LDR:02859nam a22003975i 4500 001 974990
003 DE-He213
005 20200706133935.0
007 cr nn 008mamaa
008 201211s2016 gw | s |||| 0|eng d
020 $a 9783319473888 $9 978-3-319-47388-8
024 7 $a 10.1007/978-3-319-47388-8 $2 doi
035 $a 978-3-319-47388-8
050 4 $a R856-R857
072 7 $a MQW $2 bicssc
072 7 $a MED003040 $2 bisacsh
072 7 $a MQW $2 thema
082 0 4 $a 610.28 $2 23
100 1 $a Koča, Jaroslav. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1269620
245 1 0 $a Structural Bioinformatics Tools for Drug Design $h [electronic resource] : $b Extraction of Biologically Relevant Information from Structural Databases / $c by Jaroslav Koča, Radka Svobodová Vařeková, Lukáš Pravda, Karel Berka, Stanislav Geidl, David Sehnal, Michal Otyepka.
250 $a 1st ed. 2016.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a XIII, 144 p. 62 illus. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a SpringerBriefs in Biochemistry and Molecular Biology, $x 2211-9353
505 0 $a 1. Introduction -- 2. Biomacromolecular fragments -- 3. Databases -- 4. Detection & Extraction -- a. Biomacromolecular fragments and structural patterns -- b. channels and pores -- 5. Validation -- 6. Characterization -- a. Partial atomic charges -- b. Channel characteristics -- 7. Selected Examples.
520 $a A large amount of structural data on biomacromolecules is available and the number of resolved structures is growing rapidly. This implies that we have an increasing opportunity to perform so far unprecedented analyses to obtain crucial biological insight. Biomacromolecular structural fragments such as binding sites or active sites, ligands, channels, pores, secondary structure motifs, etc., become very promising objects for these analyses because such fragments often serve as drug targets or drug templates, or substrate-specific pathways. However, such analyses are very challenging due to their complexity and, consequently, also because they require application of a combination of different software tools. In this book, we describe individual steps necessary for analysis of biomacromolecular fragments and provide a lsit of software tools required to perform such steps. For each step, we also show corresponding web-based tools in detail and provide a few practical examples of their usage.
650 0 $a Biomedical engineering. $3 588770
650 0 $a Bioinformatics. $3 583857
650 1 4 $a Biomedical Engineering/Biotechnology. $3 1068811
650 2 4 $a Computational Biology/Bioinformatics. $3 677363
700 1 $a Svobodová Vařeková, Radka. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1269621
700 1 $a Pravda, Lukáš. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1269622
700 1 $a Berka, Karel. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1269623
700 1 $a Geidl, Stanislav. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1269624
700 1 $a Sehnal, David. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1269625
700 1 $a Otyepka, Michal. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1269626
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783319473871
776 0 8 $i Printed edition: $z 9783319473895
830 0 $a SpringerBriefs in Biochemistry and Molecular Biology, $x 2211-9353 $3 1255030
856 4 0 $u https://doi.org/10.1007/978-3-319-47388-8
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)