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Interleukin-27: Biological Properties and Clinical Application

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Interleukin-27: Biological Properties and Clinical Application/ by Marek Jankowski, Tomasz Wandtke.
作者:	Jankowski, Marek.
其他作者:	Wandtke, Tomasz.
面頁冊數:	VI, 86 p. 5 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Immunology. -
電子資源:	https://doi.org/10.1007/978-3-319-39664-4
ISBN:	9783319396644

Interleukin-27: Biological Properties and Clinical Application
Jankowski, Marek.

Interleukin-27: Biological Properties and Clinical Application[electronic resource] /by Marek Jankowski, Tomasz Wandtke. - 1st ed. 2016. - VI, 86 p. 5 illus. in color.online resource. - SpringerBriefs in Immunology,2194-2773. - SpringerBriefs in Immunology,.

IL-27: Structure, Regulation and Variability -- IL-27: A Key Player in Immune Regulation -- IL-27 in Health and Disease.

This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.

ISBN: 9783319396644

Standard No.: 10.1007/978-3-319-39664-4doiSubjects--Topical Terms:

592892
Immunology.

LC Class. No.: QR180-189.5

Dewey Class. No.: 616.079

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