國立虎尾科技大學 |

Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs/ edited by Tony K. L. Kiang, Kyle John Wilby, Mary H. H. Ensom.
other author:	Kiang, Tony K. L.
Description:	VII, 135 p. 40 illus., 25 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Pharmacology. -
Online resource:	https://doi.org/10.1007/978-981-10-2113-8
ISBN:	9789811021138

Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs
Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs[electronic resource] /edited by Tony K. L. Kiang, Kyle John Wilby, Mary H. H. Ensom. - 1st ed. 2016. - VII, 135 p. 40 illus., 25 illus. in color.online resource.

1. Introduction -- 2. HIV-Associated Comorbidities -- 3. Pharmacology and Pharmacokinetic Properties of Available Antiretrovirals -- 4. In Vitro Reaction Phenotyping and Drug Interaction Data -- 5. Clinical Drug-Drug Interaction Data: Effects of Co-administered Drugs on Pharmacokinetics of Antiretroviral Agents -- 6. Clinical Drug-Drug Interaction Data: Effects of Antiretroviral Agents on Co-administered Drugs -- 7. Pharmacodynamic Interactions Between Antiretrovirals and Other Agents -- 8. Conclusion and Clinical Decision Algorithm.

Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers, this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the interactions is systematically evaluated and gaps in literature discussed in the context of potential future experiments. In addition to the comprehensive summary of pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antiretroviral drugs on the market today (i.e. nucleotide reverse-transcriptase inhibitors, non-nucleoside reverse-transcriptase inhibitors, integrase inhibitors, and protease inhibitors), this book also provides detailed section summaries on the epidemiology of HIV infection, diagnosis and pharmacotherapy, basic pharmacology of the individual antiretrovirals, pertinent pre-clinical and in vitro molecular pharmacology, and in vitro drug interaction data available in the literature today. .

ISBN: 9789811021138

Standard No.: 10.1007/978-981-10-2113-8doiSubjects--Topical Terms:

583819
Pharmacology.

LC Class. No.: RM1-950

Dewey Class. No.: 615

Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs
LDR:03198nam a22003975i 4500 001 978145
003 DE-He213
005 20200629185833.0
007 cr nn 008mamaa
008 201211s2016 si | s |||| 0|eng d
020 $a 9789811021138 $9 978-981-10-2113-8
024 7 $a 10.1007/978-981-10-2113-8 $2 doi
035 $a 978-981-10-2113-8
050 4 $a RM1-950
072 7 $a MMG $2 bicssc
072 7 $a MED071000 $2 bisacsh
072 7 $a MKG $2 thema
082 0 4 $a 615 $2 23
245 1 0 $a Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs $h [electronic resource] / $c edited by Tony K. L. Kiang, Kyle John Wilby, Mary H. H. Ensom.
250 $a 1st ed. 2016.
264 1 $a Singapore : $b Springer Singapore : $b Imprint: Adis, $c 2016.
300 $a VII, 135 p. 40 illus., 25 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a 1. Introduction -- 2. HIV-Associated Comorbidities -- 3. Pharmacology and Pharmacokinetic Properties of Available Antiretrovirals -- 4. In Vitro Reaction Phenotyping and Drug Interaction Data -- 5. Clinical Drug-Drug Interaction Data: Effects of Co-administered Drugs on Pharmacokinetics of Antiretroviral Agents -- 6. Clinical Drug-Drug Interaction Data: Effects of Antiretroviral Agents on Co-administered Drugs -- 7. Pharmacodynamic Interactions Between Antiretrovirals and Other Agents -- 8. Conclusion and Clinical Decision Algorithm.
520 $a Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers, this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the interactions is systematically evaluated and gaps in literature discussed in the context of potential future experiments. In addition to the comprehensive summary of pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antiretroviral drugs on the market today (i.e. nucleotide reverse-transcriptase inhibitors, non-nucleoside reverse-transcriptase inhibitors, integrase inhibitors, and protease inhibitors), this book also provides detailed section summaries on the epidemiology of HIV infection, diagnosis and pharmacotherapy, basic pharmacology of the individual antiretrovirals, pertinent pre-clinical and in vitro molecular pharmacology, and in vitro drug interaction data available in the literature today. .
650 0 $a Pharmacology. $3 583819
650 0 $a Infectious diseases. $3 1102043
650 1 4 $a Pharmacology/Toxicology. $3 593882
650 2 4 $a Infectious Diseases. $3 668393
700 1 $a Kiang, Tony K. L. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1271711
700 1 $a Wilby, Kyle John. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1064647
700 1 $a Ensom, Mary H. H. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1271712
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9789811021121
776 0 8 $i Printed edition: $z 9789811021145
776 0 8 $i Printed edition: $z 9789811095306
856 4 0 $u https://doi.org/10.1007/978-981-10-2113-8
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)