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Formulating Poorly Water Soluble Drugs
~
Williams III, Robert O.
Formulating Poorly Water Soluble Drugs
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Formulating Poorly Water Soluble Drugs/ edited by Robert O. Williams III, Alan B. Watts, Dave A. Miller.
其他作者:
Williams III, Robert O.
面頁冊數:
XIV, 779 p. 210 illus., 84 illus. in color.online resource. :
Contained By:
Springer Nature eBook
標題:
Pharmaceutical technology. -
電子資源:
https://doi.org/10.1007/978-3-319-42609-9
ISBN:
9783319426099
Formulating Poorly Water Soluble Drugs
Formulating Poorly Water Soluble Drugs
[electronic resource] /edited by Robert O. Williams III, Alan B. Watts, Dave A. Miller. - 2nd ed. 2016. - XIV, 779 p. 210 illus., 84 illus. in color.online resource. - AAPS Advances in the Pharmaceutical Sciences Series,222210-7371 ;. - AAPS Advances in the Pharmaceutical Sciences Series,20.
Route-Specific Challenges in Delivery of Poorly Water Soluble Drugs -- Optimizing the Formulation of Poorly Water Soluble Drugs -- Solid-State Techniques for Improving Solubility -- Mechanical Particle Size Reduction Techniques -- Solubilized Formulations -- Injectable Formulations of Poorly Water Soluble Drugs -- Design and Development of Self-Emulsifying Lipid Formulations for Improving Oral Bioavailability of Poorly Water-Soluble and Lipophilic Drugs -- Structured Development Approach for Amorphous Systems -- Melt Extrusion -- Spray Drying Technology -- Pharmaceutical Cryogenic Technologies -- Precipitation Technologies for Nanoparticle Production -- Emerging Technologies to Increase the Bioavailability of Poorly Water Soluble Drugs -- Regulatory Considerations for Development and Commercialization of Poorly Water Soluble Drugs.
The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.
ISBN: 9783319426099
Standard No.: 10.1007/978-3-319-42609-9doiSubjects--Topical Terms:
557391
Pharmaceutical technology.
LC Class. No.: RS380
Dewey Class. No.: 615.19
Formulating Poorly Water Soluble Drugs
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