國立虎尾科技大學 |

Disordered Vertebral and Rib Morphology in Pudgy Mice = Structural Relationships to Human Congenital Scoliosis /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Disordered Vertebral and Rib Morphology in Pudgy Mice/ by Frederic Shapiro.
其他題名:	Structural Relationships to Human Congenital Scoliosis /
作者:	Shapiro, Frederic.
面頁冊數:	IX, 123 p. 20 illus., 15 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Human genetics. -
電子資源:	https://doi.org/10.1007/978-3-319-43151-2
ISBN:	9783319431512

Disordered Vertebral and Rib Morphology in Pudgy Mice = Structural Relationships to Human Congenital Scoliosis /
Shapiro, Frederic.

Disordered Vertebral and Rib Morphology in Pudgy MiceStructural Relationships to Human Congenital Scoliosis /[electronic resource] :by Frederic Shapiro. - 1st ed. 2016. - IX, 123 p. 20 illus., 15 illus. in color.online resource. - Advances in Anatomy, Embryology and Cell Biology,2210301-5556 ;. - Advances in Anatomy, Embryology and Cell Biology,217.

I. INTRODUCTION -- II. MATERIALS AND METHODS -- 1. Source, distribution, and ages of pudgy and non-affected mice. - 2. Whole mount preparations -- 3. Radiographic studies -- 4. Histologic studies -- 5. Computerized three-dimensional reconstructions -- 6. Previous studies on chick vertebral development and human congenital scoliosis -- III. RESULTS -- 1. Gross appearance -- 2. Whole mount appearances -- 3. Radiographic studies -- 4. Histology studies: vertebrae, ribs, intervertebral discs and ganglia -- 5. Computerized three-dimensional reconstructions -- 6. Chick embryo vertebral development -- 7. Radiology and histopathology of human congenital scoliosis spine -- IV. DISCUSSION -- ion -- 3. The pudgy mouse -- 4. Genetic influences on axial development; mutations identified in mouse models with vertebral deformation -- 5. Congenital scoliosis (human); its similarity with pudgy mouse vertebral abnormalities -- 6. Pathogenesis of pudgy and human congenital scoliosis based on histopathologic studies.-V. CONCLUSIONS -- 1. Implications of pudgy vertebral abnormalities for biologic research -- 2. Implications of pudgy vertebral abnormalities for clinical patient treatment. .

This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.

ISBN: 9783319431512

Standard No.: 10.1007/978-3-319-43151-2doiSubjects--Topical Terms:

596505
Human genetics.

LC Class. No.: RB155-155.8

Dewey Class. No.: 611.01816

Disordered Vertebral and Rib Morphology in Pudgy Mice = Structural Relationships to Human Congenital Scoliosis /
LDR:03747nam a22004215i 4500 001 981754
003 DE-He213
005 20200705225702.0
007 cr nn 008mamaa
008 201211s2016 gw | s |||| 0|eng d
020 $a 9783319431512 $9 978-3-319-43151-2
024 7 $a 10.1007/978-3-319-43151-2 $2 doi
035 $a 978-3-319-43151-2
050 4 $a RB155-155.8
050 4 $a QH431
072 7 $a MFN $2 bicssc
072 7 $a MED107000 $2 bisacsh
072 7 $a MFN $2 thema
082 0 4 $a 611.01816 $2 23
082 0 4 $a 599.935 $2 23
100 1 $a Shapiro, Frederic. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 862865
245 1 0 $a Disordered Vertebral and Rib Morphology in Pudgy Mice $h [electronic resource] : $b Structural Relationships to Human Congenital Scoliosis / $c by Frederic Shapiro.
250 $a 1st ed. 2016.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a IX, 123 p. 20 illus., 15 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Advances in Anatomy, Embryology and Cell Biology, $x 0301-5556 ; $v 221
505 0 $a I. INTRODUCTION -- II. MATERIALS AND METHODS -- 1. Source, distribution, and ages of pudgy and non-affected mice. - 2. Whole mount preparations -- 3. Radiographic studies -- 4. Histologic studies -- 5. Computerized three-dimensional reconstructions -- 6. Previous studies on chick vertebral development and human congenital scoliosis -- III. RESULTS -- 1. Gross appearance -- 2. Whole mount appearances -- 3. Radiographic studies -- 4. Histology studies: vertebrae, ribs, intervertebral discs and ganglia -- 5. Computerized three-dimensional reconstructions -- 6. Chick embryo vertebral development -- 7. Radiology and histopathology of human congenital scoliosis spine -- IV. DISCUSSION -- ion -- 3. The pudgy mouse -- 4. Genetic influences on axial development; mutations identified in mouse models with vertebral deformation -- 5. Congenital scoliosis (human); its similarity with pudgy mouse vertebral abnormalities -- 6. Pathogenesis of pudgy and human congenital scoliosis based on histopathologic studies.-V. CONCLUSIONS -- 1. Implications of pudgy vertebral abnormalities for biologic research -- 2. Implications of pudgy vertebral abnormalities for clinical patient treatment. .
520 $a This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.
650 0 $a Human genetics. $3 596505
650 0 $a Animal anatomy. $3 1257199
650 0 $a Animal models in research. $3 581737
650 1 4 $a Human Genetics. $3 593893
650 2 4 $a Animal Anatomy / Morphology / Histology. $3 668394
650 2 4 $a Animal Models. $3 784995
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783319431499
776 0 8 $i Printed edition: $z 9783319431505
830 0 $a Advances in Anatomy, Embryology and Cell Biology, $x 0301-5556 ; $v 217 $3 1261474
856 4 0 $u https://doi.org/10.1007/978-3-319-43151-2
912 $a ZDB-2-SME
912 $a ZDB-2-SXM
950 $a Medicine (SpringerNature-11650)
950 $a Medicine (R0) (SpringerNature-43714)