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Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology/ by Witold Lasek, Radoslaw Zagozdzon.
Author:	Lasek, Witold.
other author:	Zagozdzon, Radoslaw.
Description:	VII, 75 p. 6 illus.online resource. :
Contained By:	Springer Nature eBook
Subject:	Immunology. -
Online resource:	https://doi.org/10.1007/978-3-319-46906-5
ISBN:	9783319469065

Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology
Lasek, Witold.

Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology[electronic resource] /by Witold Lasek, Radoslaw Zagozdzon. - 1st ed. 2016. - VII, 75 p. 6 illus.online resource. - SpringerBriefs in Immunology,2194-2773. - SpringerBriefs in Immunology,.

This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).

ISBN: 9783319469065

Standard No.: 10.1007/978-3-319-46906-5doiSubjects--Topical Terms:

592892
Immunology.

LC Class. No.: QR180-189.5

Dewey Class. No.: 616.079

Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology
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