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Molecular Dynamics Analyses of Prion Protein Structures = The Resistance to Prion Diseases Down Under /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Molecular Dynamics Analyses of Prion Protein Structures/ by Jiapu Zhang.
其他題名:	The Resistance to Prion Diseases Down Under /
作者:	Zhang, Jiapu.
面頁冊數:	XXIX, 375 p. 596 illus., 278 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Proteomics. -
電子資源:	https://doi.org/10.1007/978-981-10-8815-5
ISBN:	9789811088155

Molecular Dynamics Analyses of Prion Protein Structures = The Resistance to Prion Diseases Down Under /
Zhang, Jiapu.

Molecular Dynamics Analyses of Prion Protein StructuresThe Resistance to Prion Diseases Down Under /[electronic resource] :by Jiapu Zhang. - 1st ed. 2018. - XXIX, 375 p. 596 illus., 278 illus. in color.online resource. - Focus on Structural Biology,101571-4853 ;. - Focus on Structural Biology,9.

Preface -- Basic Knowledge -- Part I Prion Resistance Species -- Rabbits -Wild-type and Mutants -- Dogs -Wild-type and D159NMutant -- Horses, Buffaloes, and Pigs -- Chicken, Turtles, and Frogs -- Other Species -- Part II b 2-a2 Loop -- Wild-type Mouse 37 oC and 19.85 oC Structures -- Mouse Mutants -- Other Species with an Ordered b 2-a2 -- Part III Human Mutants -- Human Mutants -- Human PrPC Monomer, Dimer and Its M129V Mutant -- Human Peptides -- Part IV PrP Binding/Docking -- PrP Bounded to Antibodies, Nanobody, RNA aptamer, etc -- Potential Antiprion Drugs -- Part V Prion Peptides with Cross-b Structures -- Mathematical Formulas for All PrP Peptides’ cross-b structures -- Hydrogen Bonds Between Two Optimized Fundamental Chains of Each Model -- References. .

Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational” diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book. Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the β2-α2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Sträussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book. Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-β structure PrP peptides are well studied. This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.

ISBN: 9789811088155

Standard No.: 10.1007/978-981-10-8815-5doiSubjects--Topical Terms:

581930
Proteomics.

LC Class. No.: QD431-431.7

Dewey Class. No.: 572.6

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