國立虎尾科技大學 |

Neurotoxicity of Aluminum

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Neurotoxicity of Aluminum/ edited by Qiao Niu.
其他作者:	Niu, Qiao.
面頁冊數:	VII, 191 p. 25 illus., 13 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Neurosciences. -
電子資源:	https://doi.org/10.1007/978-981-13-1370-7
ISBN:	9789811313707

Neurotoxicity of Aluminum
Neurotoxicity of Aluminum[electronic resource] /edited by Qiao Niu. - 1st ed. 2018. - VII, 191 p. 25 illus., 13 illus. in color.online resource. - Advances in Experimental Medicine and Biology,10910065-2598 ;. - Advances in Experimental Medicine and Biology,889.

Overview of the relationship between aluminum exposure and health of human being -- The Chemistry of Human Exposure to Aluminum -- Entry and Deposit of Aluminum in Brain -- Aluminum as a CNS and immune system toxin across the life span -- Occupational exposure to aluminum and cognitive impairment -- Exposure to aluminum in daily life and Alzheimer’s disease -- Animal model of aluminum-induced Alzheimer’s Disease -- Aluminum induced neural cells death -- Aluminum-induced electrophysiological variation, synaptic plasticity impairment and related mechanism -- Cross talk between Aluminum and genetic susceptibility and epigenetic modification in Alzheimer’s disease.

This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity. .

ISBN: 9789811313707

Standard No.: 10.1007/978-981-13-1370-7doiSubjects--Topical Terms:

593561
Neurosciences.

LC Class. No.: RC321-580

Dewey Class. No.: 612.8

Neurotoxicity of Aluminum
LDR:03081nam a22004095i 4500 001 989436
003 DE-He213
005 20200629161947.0
007 cr nn 008mamaa
008 201225s2018 si | s |||| 0|eng d
020 $a 9789811313707 $9 978-981-13-1370-7
024 7 $a 10.1007/978-981-13-1370-7 $2 doi
035 $a 978-981-13-1370-7
050 4 $a RC321-580
072 7 $a PSAN $2 bicssc
072 7 $a MED057000 $2 bisacsh
072 7 $a PSAN $2 thema
082 0 4 $a 612.8 $2 23
245 1 0 $a Neurotoxicity of Aluminum $h [electronic resource] / $c edited by Qiao Niu.
250 $a 1st ed. 2018.
264 1 $a Singapore : $b Springer Singapore : $b Imprint: Springer, $c 2018.
300 $a VII, 191 p. 25 illus., 13 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Advances in Experimental Medicine and Biology, $x 0065-2598 ; $v 1091
505 0 $a Overview of the relationship between aluminum exposure and health of human being -- The Chemistry of Human Exposure to Aluminum -- Entry and Deposit of Aluminum in Brain -- Aluminum as a CNS and immune system toxin across the life span -- Occupational exposure to aluminum and cognitive impairment -- Exposure to aluminum in daily life and Alzheimer’s disease -- Animal model of aluminum-induced Alzheimer’s Disease -- Aluminum induced neural cells death -- Aluminum-induced electrophysiological variation, synaptic plasticity impairment and related mechanism -- Cross talk between Aluminum and genetic susceptibility and epigenetic modification in Alzheimer’s disease.
520 $a This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity. .
650 0 $a Neurosciences. $3 593561
650 0 $a Pharmacology. $3 583819
650 0 $a Neurobiology. $3 573189
650 2 4 $a Pharmacology/Toxicology. $3 593882
700 1 $a Niu, Qiao. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1210072
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9789811313691
776 0 8 $i Printed edition: $z 9789811313714
776 0 8 $i Printed edition: $z 9789811346217
830 0 $a Advances in Experimental Medicine and Biology, $x 0065-2598 ; $v 889 $3 1253792
856 4 0 $u https://doi.org/10.1007/978-981-13-1370-7
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)