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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins/ by Raphael Enoque Ferraz de Paiva.
作者:	Ferraz de Paiva, Raphael Enoque.
面頁冊數:	XXXIX, 151 p. 100 illus., 38 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Inorganic chemistry. -
電子資源:	https://doi.org/10.1007/978-3-030-00853-6
ISBN:	9783030008536

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Ferraz de Paiva, Raphael Enoque.

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins[electronic resource] /by Raphael Enoque Ferraz de Paiva. - 1st ed. 2018. - XXXIX, 151 p. 100 illus., 38 illus. in color.online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053. - Springer Theses, Recognizing Outstanding Ph.D. Research,.

Au(I)-phosphine series design -- Probing the Protein: Ion Mobility Spectrometry -- Probing Gold: X-ray Absorption Spectroscopy -- Probing Cells: Cytotoxicity Evaluation -- Au(III) series with k2C,N and k2N,N' ligands -- "Dual Probe" X-ray Absorption Spectroscopy.

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

ISBN: 9783030008536

Standard No.: 10.1007/978-3-030-00853-6doiSubjects--Topical Terms:

1182077
Inorganic chemistry.

LC Class. No.: QD146-197

Dewey Class. No.: 546

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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520 $a This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
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