國立虎尾科技大學 |

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins/ by Raphael Enoque Ferraz de Paiva.
Author:	Ferraz de Paiva, Raphael Enoque.
Description:	XXXIX, 151 p. 100 illus., 38 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Inorganic chemistry. -
Online resource:	https://doi.org/10.1007/978-3-030-00853-6
ISBN:	9783030008536

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Ferraz de Paiva, Raphael Enoque.

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins[electronic resource] /by Raphael Enoque Ferraz de Paiva. - 1st ed. 2018. - XXXIX, 151 p. 100 illus., 38 illus. in color.online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053. - Springer Theses, Recognizing Outstanding Ph.D. Research,.

Au(I)-phosphine series design -- Probing the Protein: Ion Mobility Spectrometry -- Probing Gold: X-ray Absorption Spectroscopy -- Probing Cells: Cytotoxicity Evaluation -- Au(III) series with k2C,N and k2N,N' ligands -- "Dual Probe" X-ray Absorption Spectroscopy.

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

ISBN: 9783030008536

Standard No.: 10.1007/978-3-030-00853-6doiSubjects--Topical Terms:

1182077
Inorganic chemistry.

LC Class. No.: QD146-197

Dewey Class. No.: 546

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
LDR:02618nam a22004095i 4500 001 989467
003 DE-He213
005 20200705172916.0
007 cr nn 008mamaa
008 201225s2018 gw | s |||| 0|eng d
020 $a 9783030008536 $9 978-3-030-00853-6
024 7 $a 10.1007/978-3-030-00853-6 $2 doi
035 $a 978-3-030-00853-6
050 4 $a QD146-197
072 7 $a PNK $2 bicssc
072 7 $a SCI013030 $2 bisacsh
072 7 $a PNK $2 thema
082 0 4 $a 546 $2 23
100 1 $a Ferraz de Paiva, Raphael Enoque. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1209155
245 1 0 $a Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins $h [electronic resource] / $c by Raphael Enoque Ferraz de Paiva.
250 $a 1st ed. 2018.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2018.
300 $a XXXIX, 151 p. 100 illus., 38 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Springer Theses, Recognizing Outstanding Ph.D. Research, $x 2190-5053
505 0 $a Au(I)-phosphine series design -- Probing the Protein: Ion Mobility Spectrometry -- Probing Gold: X-ray Absorption Spectroscopy -- Probing Cells: Cytotoxicity Evaluation -- Au(III) series with k2C,N and k2N,N' ligands -- "Dual Probe" X-ray Absorption Spectroscopy.
520 $a This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
650 0 $a Inorganic chemistry. $3 1182077
650 0 $a Organometallic chemistry . $3 1254952
650 0 $a Proteins . $3 1253493
650 0 $a Mass spectrometry. $3 583253
650 0 $a Bioorganic chemistry. $3 743635
650 0 $a Immunology. $3 592892
650 1 4 $a Inorganic Chemistry. $3 671307
650 2 4 $a Organometallic Chemistry. $3 674440
650 2 4 $a Protein-Ligand Interactions. $3 882815
650 2 4 $a Mass Spectrometry. $3 782160
650 2 4 $a Bioorganic Chemistry. $3 677511
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783030008529
776 0 8 $i Printed edition: $z 9783030008543
776 0 8 $i Printed edition: $z 9783030131500
830 0 $a Springer Theses, Recognizing Outstanding Ph.D. Research, $x 2190-5053 $3 1253569
856 4 0 $u https://doi.org/10.1007/978-3-030-00853-6
912 $a ZDB-2-CMS
912 $a ZDB-2-SXC
950 $a Chemistry and Materials Science (SpringerNature-11644)
950 $a Chemistry and Material Science (R0) (SpringerNature-43709)