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HIV-1 Latency

Record Type:	Language materials, printed : Monograph/item
Title/Author:	HIV-1 Latency/ edited by Guido Silvestri, Mathias Lichterfeld.
other author:	Silvestri, Guido.
Description:	VII, 248 p.online resource. :
Contained By:	Springer Nature eBook
Subject:	Immunology. -
Online resource:	https://doi.org/10.1007/978-3-030-02816-9
ISBN:	9783030028169

HIV-1 Latency
HIV-1 Latency[electronic resource] /edited by Guido Silvestri, Mathias Lichterfeld. - 1st ed. 2018. - VII, 248 p.online resource. - Current Topics in Microbiology and Immunology,4170070-217X ;. - Current Topics in Microbiology and Immunology,387.

Molecular Control of HIV and SIV Latency -- Assays to Measure Latency, Reservoirs and Reactivation -- The Antiviral Immune Response and its Impact on the HIV-1 Reservoir -- Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy -- SIV Latency in Macrophages in the CNS -- Mathematical models of HIV latency -- Residual Immune Activation and Latency -- Immune Interventions to Eliminate the HIV Reservoir -- Cell and Gene Therapy for HIV Cure.

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

ISBN: 9783030028169

Standard No.: 10.1007/978-3-030-02816-9doiSubjects--Topical Terms:

592892
Immunology.

LC Class. No.: QR180-189.5

Dewey Class. No.: 616.079

HIV-1 Latency
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