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Drug Resistance in Leishmania Parasites = Consequences, Molecular Mechanisms and Possible Treatments /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Drug Resistance in Leishmania Parasites/ edited by Alicia Ponte-Sucre, Maritza Padrón-Nieves.
其他題名:	Consequences, Molecular Mechanisms and Possible Treatments /
其他作者:	Ponte-Sucre, Alicia.
面頁冊數:	XVII, 376 p. 24 illus., 14 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Drug resistance. -
電子資源:	https://doi.org/10.1007/978-3-319-74186-4
ISBN:	9783319741864

Drug Resistance in Leishmania Parasites = Consequences, Molecular Mechanisms and Possible Treatments /
Drug Resistance in Leishmania ParasitesConsequences, Molecular Mechanisms and Possible Treatments /[electronic resource] :edited by Alicia Ponte-Sucre, Maritza Padrón-Nieves. - 2nd ed. 2018. - XVII, 376 p. 24 illus., 14 illus. in color.online resource.

Prologue -- Introduction -- Part I Determinant features in Leishmaniasis -- Molecular evolution and phylogeny of Leishmania -- The role of reservoirs: canine Leishmaniasis -- Epidemiology of Leishmaniasis in the time of drug resistance -- The role of the immune system in resistance to infection -- Part II Challenges in the diagnosis, treatment and control of Leishmaniasis in the times of drug resistance -- Co-infection with HIV -- Visceral Leishmaniasis -- Tegumentary Leishmaniasis -- Antimony accounted sequel post Kala-Azar dermal Leishmaniasis -- Part III Molecular featrues of drug resistant Leishmania -- Genetic Expression and drug resistance, the role of proteomics -- The role of AMC transporters in drug-resistant Leishmania -- Functional analysis of Leishmania membrane (non AMC) transporters involved in drug resistance -- Part IV Pharmacology and chemotherapy of Leishmaniasis -- Classical vs. novel treatment regimens -- Bioinformatics in Leishmania drug design -- Leishmanis mitochondria, a druggable organelle -- P-glycoprotein-like transporters in Leishmania: a search for reversal agents -- Part V Strategies to circumvent drug resistance in Leishmania -- The relevance of susceptibility tests, breakpoints and markers -- The concept of fitness in Leishmania.

Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the second edition of a well-received book that provides a comprehensive update on the pathology of the disease, as well as on the concept of parasitic drug resistance, its molecular basis, consequences and possible treatments. A valuable resource for scientists both from academia and industry involved in biomedical research and drug design, the book provides the knowledge needed to understand leishmaniasis and to contibute to combatting this disease worldwide.

ISBN: 9783319741864

Standard No.: 10.1007/978-3-319-74186-4doiSubjects--Topical Terms:

872072
Drug resistance.

LC Class. No.: QR177

Dewey Class. No.: 616.9041

Drug Resistance in Leishmania Parasites = Consequences, Molecular Mechanisms and Possible Treatments /
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