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Targeting Trafficking in Drug Development

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Targeting Trafficking in Drug Development/ edited by Alfredo Ulloa-Aguirre, Ya-Xiong Tao.
其他作者:	Ulloa-Aguirre, Alfredo.
面頁冊數:	VIII, 425 p. 57 illus.online resource. :
Contained By:	Springer Nature eBook
標題:	Pharmacology. -
電子資源:	https://doi.org/10.1007/978-3-319-74164-2
ISBN:	9783319741642

Targeting Trafficking in Drug Development
Targeting Trafficking in Drug Development[electronic resource] /edited by Alfredo Ulloa-Aguirre, Ya-Xiong Tao. - 1st ed. 2018. - VIII, 425 p. 57 illus.online resource. - Handbook of Experimental Pharmacology,2450171-2004 ;. - Handbook of Experimental Pharmacology,224.

1. Intracellular trafficking of gonadotropin receptors in health and disease -- 2. Investigating internalization and intracellular trafficking of GPCRs -- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors -- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases -- 5. Pharmacoperones for misfolded gonadotropin receptors -- 6. Pharmacological chaperones: Beyond conformational disorders -- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer -- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches -- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking -- 10. SLC6 transporter folding diseases and pharmacochaperoning -- 11. The molecular physiopathogenesis of islet amyloidosis -- 12. Folding defects leading to primary hyperoxaluria -- 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. .

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

ISBN: 9783319741642

Standard No.: 10.1007/978-3-319-74164-2doiSubjects--Topical Terms:

583819
Pharmacology.

LC Class. No.: RM1-950

Dewey Class. No.: 615

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