國立虎尾科技大學 |

Sesquiterpene Lactones = Advances in their Chemistry and Biological Aspects /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Sesquiterpene Lactones/ edited by Valeria Patricia Sülsen, Virginia Susana Martino.
Reminder of title:	Advances in their Chemistry and Biological Aspects /
other author:	Sülsen, Valeria Patricia.
Description:	XXII, 371 p. 172 illus., 14 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Medicinal chemistry. -
Online resource:	https://doi.org/10.1007/978-3-319-78274-4
ISBN:	9783319782744

Sesquiterpene Lactones = Advances in their Chemistry and Biological Aspects /
Sesquiterpene LactonesAdvances in their Chemistry and Biological Aspects /[electronic resource] :edited by Valeria Patricia Sülsen, Virginia Susana Martino. - 1st ed. 2018. - XXII, 371 p. 172 illus., 14 illus. in color.online resource.

Part1. Chemical and biochemical aspects of sesquiterpene lactones -- Chapter1. Overview -- Chapter2. Ancient and modern concepts about the asteraceae taxonomy -- Chapter3. Chemotaxonomic study of sesquiterpene lactones of asteraceae: classical and modern methods -- Chapter4. Biosynthesis of sesquiterpene lactones in plants and metabolic engineering for their biotechnological production -- Chapter5. Chemistry of sesquiterpene lactones -- Chapter6. Analytical procedures -- Chapter7. Spectroscopic methods for the identification of sesquiterpene lactones -- Part2. Biological activities of sesquiterpene lactones -- Chapter8. Antitrypanosomal and antileishmanial activities -- Chapter9. Antiplasmodial activity -- Chapter10. Mode of action on trypanosoma and leishmania spp -- Chapter11. Contribution of microscopy for understanding the mechanism of action against trypanosomatids -- Chapter12. Effects on other microorganisms -- Chapter13. Antiproliferative and cytotoxic activities -- Chapter14. Anti-inflammatory activity -- Part3. Sesquiterpene lactones: medicinal chemistry approach -- Chapter15. Structure-activity and activity-activity relationships of sesquiterpene lactones.

This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis, derivatization and QSAR analysis. Taxonomic and chemotaxonomic aspects related to the Asteraceae family are also contributed. The book begins by describing the chemical characteristics of STLs, their classification in different skeleton types, synthesis, distribution in nature and their most important biological properties. An overview of the group's main representatives, based on their importance for human health, as well as an update of the most recently isolated STLs, follow. The authors also provide an overview of the most common methods described in the literature for the extraction, purification, identification and structure elucidation of STLs, while also highlighting more recently developed methods. Furthermore, experts in the field provide an in-depth discussion of the most commonly employed in vitro and in vivo antiprotozoal assays against the different stages of parasites, as well as STLs' properties as anticancer agents in numerous cancer cell lines and animal models. Lastly, the book presents examples of the in vitro and in vivo activity of STLs and their mechanism of antiprotozoal action, together with an analysis of ultrastructural alterations, observed using TEM techniques. The book is aimed at scientists working on natural products: both those investigating this particular group of compounds and those who wish to further explore its potential as new drugs for medical conditions such as protozoal diseases and cancer.

ISBN: 9783319782744

Standard No.: 10.1007/978-3-319-78274-4doiSubjects--Topical Terms:

1253747
Medicinal chemistry.

LC Class. No.: RS400-431

Dewey Class. No.: 615.19

Sesquiterpene Lactones = Advances in their Chemistry and Biological Aspects /
LDR:04478nam a22003975i 4500 001 994277
003 DE-He213
005 20200703101652.0
007 cr nn 008mamaa
008 201225s2018 gw | s |||| 0|eng d
020 $a 9783319782744 $9 978-3-319-78274-4
024 7 $a 10.1007/978-3-319-78274-4 $2 doi
035 $a 978-3-319-78274-4
050 4 $a RS400-431
072 7 $a PSB $2 bicssc
072 7 $a SCI013020 $2 bisacsh
072 7 $a PSB $2 thema
082 0 4 $a 615.19 $2 23
245 1 0 $a Sesquiterpene Lactones $h [electronic resource] : $b Advances in their Chemistry and Biological Aspects / $c edited by Valeria Patricia Sülsen, Virginia Susana Martino.
250 $a 1st ed. 2018.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2018.
300 $a XXII, 371 p. 172 illus., 14 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a Part1. Chemical and biochemical aspects of sesquiterpene lactones -- Chapter1. Overview -- Chapter2. Ancient and modern concepts about the asteraceae taxonomy -- Chapter3. Chemotaxonomic study of sesquiterpene lactones of asteraceae: classical and modern methods -- Chapter4. Biosynthesis of sesquiterpene lactones in plants and metabolic engineering for their biotechnological production -- Chapter5. Chemistry of sesquiterpene lactones -- Chapter6. Analytical procedures -- Chapter7. Spectroscopic methods for the identification of sesquiterpene lactones -- Part2. Biological activities of sesquiterpene lactones -- Chapter8. Antitrypanosomal and antileishmanial activities -- Chapter9. Antiplasmodial activity -- Chapter10. Mode of action on trypanosoma and leishmania spp -- Chapter11. Contribution of microscopy for understanding the mechanism of action against trypanosomatids -- Chapter12. Effects on other microorganisms -- Chapter13. Antiproliferative and cytotoxic activities -- Chapter14. Anti-inflammatory activity -- Part3. Sesquiterpene lactones: medicinal chemistry approach -- Chapter15. Structure-activity and activity-activity relationships of sesquiterpene lactones.
520 $a This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis, derivatization and QSAR analysis. Taxonomic and chemotaxonomic aspects related to the Asteraceae family are also contributed. The book begins by describing the chemical characteristics of STLs, their classification in different skeleton types, synthesis, distribution in nature and their most important biological properties. An overview of the group's main representatives, based on their importance for human health, as well as an update of the most recently isolated STLs, follow. The authors also provide an overview of the most common methods described in the literature for the extraction, purification, identification and structure elucidation of STLs, while also highlighting more recently developed methods. Furthermore, experts in the field provide an in-depth discussion of the most commonly employed in vitro and in vivo antiprotozoal assays against the different stages of parasites, as well as STLs' properties as anticancer agents in numerous cancer cell lines and animal models. Lastly, the book presents examples of the in vitro and in vivo activity of STLs and their mechanism of antiprotozoal action, together with an analysis of ultrastructural alterations, observed using TEM techniques. The book is aimed at scientists working on natural products: both those investigating this particular group of compounds and those who wish to further explore its potential as new drugs for medical conditions such as protozoal diseases and cancer.
650 0 $a Medicinal chemistry. $3 1253747
650 0 $a Pharmacology. $3 583819
650 0 $a Organic chemistry. $3 1148722
650 0 $a Biochemistry. $3 582831
650 1 4 $a Medicinal Chemistry. $3 668872
650 2 4 $a Pharmacology/Toxicology. $3 593882
650 2 4 $a Organic Chemistry. $3 673440
650 2 4 $a Biochemistry, general. $3 593881
700 1 $a Sülsen, Valeria Patricia. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1285605
700 1 $a Martino, Virginia Susana. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1205845
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783319782737
776 0 8 $i Printed edition: $z 9783319782751
776 0 8 $i Printed edition: $z 9783030086602
856 4 0 $u https://doi.org/10.1007/978-3-319-78274-4
912 $a ZDB-2-CMS
912 $a ZDB-2-SXC
950 $a Chemistry and Materials Science (SpringerNature-11644)
950 $a Chemistry and Material Science (R0) (SpringerNature-43709)