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Chromosome Translocation

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Chromosome Translocation/ edited by Yu Zhang.
其他作者:	Zhang, Yu.
面頁冊數:	V, 168 p. 29 illus., 27 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Human genetics. -
電子資源:	https://doi.org/10.1007/978-981-13-0593-1
ISBN:	9789811305931

Chromosome Translocation
Chromosome Translocation[electronic resource] /edited by Yu Zhang. - 1st ed. 2018. - V, 168 p. 29 illus., 27 illus. in color.online resource. - Advances in Experimental Medicine and Biology,10440065-2598 ;. - Advances in Experimental Medicine and Biology,889.

Chapter 1: Historical and clinical overview of chromosome translocations -- Chapter 2: Next generation sequencing to identify chromosome translocation -- Chapter 3: The experimental models to study chromosome translocations -- Chapter 4: High throughput translocation sequencing to identify mechanistic factors shaping translocatome -- Chapter 5: Live cell imaging to study chromosome translocation -- Chapter 6: CRISPR/Cas9 to induce chromosome translocation in vivo -- Chapter 7: Generation of DNA double strand breaks (DSBs) -- Chapter 8: The role of DSB response pathway in regulating chromosome translocation -- Chapter 9: DSB repair and ligation of chromosome translocation -- Chapter 10: 3D genome organization defines the chromosome translocation pattern -- Chapter 11: Mechanisms of chromosome deletion -- Chapter 12: Chromothripsis: The role of DNA double strand break form on repair pathway selection.

This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases. The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation. It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.

ISBN: 9789811305931

Standard No.: 10.1007/978-981-13-0593-1doiSubjects--Topical Terms:

596505
Human genetics.

LC Class. No.: RB155-155.8

Dewey Class. No.: 611.01816

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