國立虎尾科技大學 |

Chemical Epigenetics

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Chemical Epigenetics/ edited by Antonello Mai.
other author:	Mai, Antonello.
Description:	IX, 567 p. 80 illus., 50 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Medicinal chemistry. -
Online resource:	https://doi.org/10.1007/978-3-030-42982-9
ISBN:	9783030429829

Chemical Epigenetics
Chemical Epigenetics[electronic resource] /edited by Antonello Mai. - 1st ed. 2020. - IX, 567 p. 80 illus., 50 illus. in color.online resource. - Topics in Medicinal Chemistry,331862-2461 ;. - Topics in Medicinal Chemistry,15.

Targeting the Zinc-Dependent Histone Deacetylases (HDACs) for Drug Discovery -- Hydroxamic Acid-Containing Peptides in the Study of Histone Deacetylases -- Sirtuin Inhibitors and Activators -- Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors -- Lysine Methyltransferases and Their Inhibitors -- PRMT Inhibitors -- Lysine-Specific Histone Demethylases 1/2 (LSD1/2) and Their Inhibitors -- Inhibitors of JmjC-Containing Histone Demethylases -- Chemical Compounds Targeting DNA Methylation and Hydroxymethylation -- Applied Biophysics for Bromodomain Drug Discovery -- Methyl-Readers and Inhibitors -- Altered Long Non-coding RNA Expression in Cancer: Potential Biomarkers and Therapeutic Targets? - Acetylation and Methylation in Asthma, COPD, and Lung Cancer -- Structure-Based Design ofEpigenetic Inhibitors -- Experimental Methodologies for Detection and Mapping of Epigenetic DNA Marks -- Advanced Assays in Epigenetics.

This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics. .

ISBN: 9783030429829

Standard No.: 10.1007/978-3-030-42982-9doiSubjects--Topical Terms:

1253747
Medicinal chemistry.

LC Class. No.: RS400-431

Dewey Class. No.: 615.19

Chemical Epigenetics
LDR:03168nam a22004095i 4500 001 1024531
003 DE-He213
005 20200704121145.0
007 cr nn 008mamaa
008 210318s2020 gw | s |||| 0|eng d
020 $a 9783030429829 $9 978-3-030-42982-9
024 7 $a 10.1007/978-3-030-42982-9 $2 doi
035 $a 978-3-030-42982-9
050 4 $a RS400-431
072 7 $a PSB $2 bicssc
072 7 $a SCI013020 $2 bisacsh
072 7 $a PSB $2 thema
082 0 4 $a 615.19 $2 23
245 1 0 $a Chemical Epigenetics $h [electronic resource] / $c edited by Antonello Mai.
250 $a 1st ed. 2020.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2020.
300 $a IX, 567 p. 80 illus., 50 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Topics in Medicinal Chemistry, $x 1862-2461 ; $v 33
505 0 $a Targeting the Zinc-Dependent Histone Deacetylases (HDACs) for Drug Discovery -- Hydroxamic Acid-Containing Peptides in the Study of Histone Deacetylases -- Sirtuin Inhibitors and Activators -- Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors -- Lysine Methyltransferases and Their Inhibitors -- PRMT Inhibitors -- Lysine-Specific Histone Demethylases 1/2 (LSD1/2) and Their Inhibitors -- Inhibitors of JmjC-Containing Histone Demethylases -- Chemical Compounds Targeting DNA Methylation and Hydroxymethylation -- Applied Biophysics for Bromodomain Drug Discovery -- Methyl-Readers and Inhibitors -- Altered Long Non-coding RNA Expression in Cancer: Potential Biomarkers and Therapeutic Targets? - Acetylation and Methylation in Asthma, COPD, and Lung Cancer -- Structure-Based Design ofEpigenetic Inhibitors -- Experimental Methodologies for Detection and Mapping of Epigenetic DNA Marks -- Advanced Assays in Epigenetics.
520 $a This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics. .
650 0 $a Medicinal chemistry. $3 1253747
650 0 $a Genetics. $3 578972
650 0 $a Enzymology. $3 782178
650 0 $a Chemical engineering. $3 555952
650 1 4 $a Medicinal Chemistry. $3 668872
650 2 4 $a Genetics and Genomics. $3 1229010
650 2 4 $a Industrial Chemistry/Chemical Engineering. $3 671153
700 1 $a Mai, Antonello. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1320705
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783030429812
776 0 8 $i Printed edition: $z 9783030429836
776 0 8 $i Printed edition: $z 9783030429843
830 0 $a Topics in Medicinal Chemistry, $x 1862-2461 ; $v 15 $3 1253746
856 4 0 $u https://doi.org/10.1007/978-3-030-42982-9
912 $a ZDB-2-CMS
912 $a ZDB-2-SXC
950 $a Chemistry and Materials Science (SpringerNature-11644)
950 $a Chemistry and Material Science (R0) (SpringerNature-43709)