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Neuroprotection in Alzheimer's disease

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Neuroprotection in Alzheimer's disease/ edited by Illana Gozes.
other author:	Gozes, Illana,
Published:	London, United Kingdom :Academic Press, : 2017.,
Description:	1 online resource
Subject:	Alzheimer's disease. -
Online resource:	https://www.sciencedirect.com/science/book/9780128036907
ISBN:	9780128037126 (electronic bk.)

Neuroprotection in Alzheimer's disease
Neuroprotection in Alzheimer's disease[electronic resource] /edited by Illana Gozes. - London, United Kingdom :Academic Press,2017. - 1 online resource

Cover; Title page; Copyright Page; Dedication; Contents; List of Contributors; Acknowledgments; Chapter 1 -- Introduction; Chapter 2 -- Neural Regeneration as a Disease-Modifying Therapeutic Strategy for Alzheimer's Disease; Introduction; Global health care burden of Alzheimer's disease: epidemiological data; Etiopathogenesis of Alzheimer's disease: what do we know?; Therapeutic approaches to Alzheimer's disease: the promises, the failures, and the future; Neural regeneration-based therapeutic approach for AD: the rationale, the promise, and the progress.

ISBN: 9780128037126 (electronic bk.)Subjects--Topical Terms:

581461
Alzheimer's disease.
Index Terms--Genre/Form:

1344907
Computer network resources.

LC Class. No.: RC523

Dewey Class. No.: 616.8/311

National Library of Medicine Call No.: 2017 D-046

Neuroprotection in Alzheimer's disease
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245 0 0 $a Neuroprotection in Alzheimer's disease $h [electronic resource] / $c edited by Illana Gozes.
260 $a London, United Kingdom : $b Academic Press, $c 2017.
300 $a 1 online resource
505 0 $a Cover; Title page; Copyright Page; Dedication; Contents; List of Contributors; Acknowledgments; Chapter 1 -- Introduction; Chapter 2 -- Neural Regeneration as a Disease-Modifying Therapeutic Strategy for Alzheimer's Disease; Introduction; Global health care burden of Alzheimer's disease: epidemiological data; Etiopathogenesis of Alzheimer's disease: what do we know?; Therapeutic approaches to Alzheimer's disease: the promises, the failures, and the future; Neural regeneration-based therapeutic approach for AD: the rationale, the promise, and the progress.
505 8 $a Neurotrophic factor small-molecule mimetics for Alzheimer's diseaseEnhancement of neurogenesis and memory by CNTF small-molecule mimetics; CNTF-derived neurogenic/neurotrophic compound, P021, can exert a disease-modifying effect in a transgenic mouse model of AD; Summary and conclusions; References; Chapter 3 -- Animal Models of Alzheimer's Disease; Introduction; The genetics of Alzheimer's disease; Transgenic models of amyloidogenesis; Amyloid precursor protein transgenic mice; PDAPP transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Tg2576 transgenic mice; Histopathology.
505 8 $a BehaviorSynaptic Plasticity; APP23 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; J20 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; APP knock-in transgenic mice; Histopathology; Behavior; Synaptic Plasticity; APP/PS1 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; 5xFAD transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Tau transgenic mice; Tau tg mice under tau promoter; Histopathology; Behavior; Synaptic Plasticity; 3xTg transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Animal models for late onset of AD.
505 8 $a ApoE Transgenic MiceApoE Knock-Out Transgenic Mice; ApoE2/ApoE3/ApoE4 Knock-In Transgenic Mice; GFAP-ApoE4/ApoE Knock-Out Transgenic Mice; ApoE/APP Transgenic Mice; Nonmouse models; Studies in nematodes; Studies in fruit flies; Nontransgenic models for the study of AD; How to choose the right model?; Summary; Acknowledgment; References; Chapter 4 -- Mechanisms of Neuronal Microtubule Loss in Alzheimer's Disease; Introduction; Studies on Alzheimer's brain and animal models; Are microtubules destabilized in the Alzheimer's brain?; Mechanisms of microtubule loss in the Alzheimer's brain.
505 8 $a Strategies for treatmentAcknowledgments; References; Chapter 5 -- Tau-Centric Therapies for Treating Alzheimer's Disease; Introduction; Six Tau Isoforms-Many Tau Functions; Mechanisms of Tau Toxicity: Phosphorylation, Microtubule Destabilization, and Aggregation; Tau-centric therapeutic strategy 1: targeting tau phosphorylation; Tau Phosphorylation in Physiological and Pathological States; Mechanisms for Stimulating Tau Phosphorylation; Consequences of Phosphorylation; Therapeutic Strategies to Inhibit Tau Phosphorylation; Current State of Affairs.
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650 0 $a Alzheimer's disease $x Prevention. $3 1110749
650 1 2 $a Alzheimer Disease $x prevention & control. $3 1344905
650 2 2 $a Neuroprotection. $3 1344906
650 7 $a HEALTH & FITNESS $x Diseases $x General. $2 bisacsh $3 862499
650 7 $a MEDICAL $x Clinical Medicine. $2 bisacsh $3 812408
650 7 $a MEDICAL $x Diseases. $2 bisacsh $3 862500
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650 7 $a MEDICAL $x Internal Medicine. $2 bisacsh $3 862781
655 0 $a Computer network resources. $3 1344907
655 4 $a Fulltext. $3 1344908
655 4 $a Internet Resources. $3 1344909
700 1 $a Gozes, Illana, $e editor. $3 1344904
856 4 0 $u https://www.sciencedirect.com/science/book/9780128036907