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Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils./
Author:	Currens, Grant C.
Description:	1 online resource (142 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 83-04, Section: B.
Contained By:	Dissertations Abstracts International83-04B.
Subject:	Pharmaceutical sciences. -
Online resource:	click for full text (PQDT)
ISBN:	9798460472284

Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils.
Currens, Grant C.

Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils. - 1 online resource (142 pages)

Source: Dissertations Abstracts International, Volume: 83-04, Section: B.

Thesis (Ph.D.)--University of North Texas Health Science Center at Fort Worth, 2021.

Includes bibliographical references

This project aimed to explore a new approach to microbial natural product discovery through collection of soil samples from strategically determined geographic sites in the State of Texas. Morphologically distinctive bacterial and fungal isolates were obtained from the soil samples and a pilot-size, semi-fractionated natural product library was constructed and screened for cytotoxicity against human cancer cell lines. Subsequently, activity-guided purification and structural identification were performed to characterize naturally occurring bioactive small molecules.Through a pilot fungal-derived natural product study, the library construction methodology was validated and known cytotoxic compounds malformin, palmitic acid, aspergillin PZ, and trichoderone B were isolated and re-identified. Their structural data and previously unknown cytotoxicity against various cancer cell lines were studied and are reported herein.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798460472284Subjects--Topical Terms:

1180569
Pharmaceutical sciences.
Subjects--Index Terms:

Drug DiscoveryIndex Terms--Genre/Form:

554714
Electronic books.

Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils.
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504 $a Includes bibliographical references
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