國立虎尾科技大學 |

Impact of Fish Oil Supplementation on Plasma Levels of Fatty Acid-Containing Lipid Classes, Lipid Molecular Species, and Biomarkers of Brain Injury in Contact Sport Athletes.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Impact of Fish Oil Supplementation on Plasma Levels of Fatty Acid-Containing Lipid Classes, Lipid Molecular Species, and Biomarkers of Brain Injury in Contact Sport Athletes./
Author:	Mullins, Veronica Anne.
Description:	1 online resource (129 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-06, Section: B.
Contained By:	Dissertations Abstracts International85-06B.
Subject:	Nutrition. -
Online resource:	click for full text (PQDT)
ISBN:	9798381097221

Impact of Fish Oil Supplementation on Plasma Levels of Fatty Acid-Containing Lipid Classes, Lipid Molecular Species, and Biomarkers of Brain Injury in Contact Sport Athletes.
Mullins, Veronica Anne.

Impact of Fish Oil Supplementation on Plasma Levels of Fatty Acid-Containing Lipid Classes, Lipid Molecular Species, and Biomarkers of Brain Injury in Contact Sport Athletes. - 1 online resource (129 pages)

Source: Dissertations Abstracts International, Volume: 85-06, Section: B.

Thesis (Ph.D.)--The University of Arizona, 2023.

Includes bibliographical references

Contact sports involve a high risk of concussive injury and a higher risk of injury from repeated subconcussive head impacts (RSHI) that do not meet the threshold for a concussion diagnosis. RSHI increase an athlete's risk of biochemical and structural brain damage that can lead to cognitive and behavioral deficits later in life. Omega-3 highly unsaturated fatty acids, docosahexaenoic acids (DHA) and eicosapentaenoic acids (EPA), found in fish oil supplements and fatty fish, produce biologically active molecules that resolve inflammation and therefore their use in brain injury recovery has garnered substantial interest within the field of sports medicine research. The work reported in this dissertation was undertaken in response to the urgent need to better understand the risks of RSHI and the potential for omega-3 highly unsaturated fatty acids to mitigate the trauma. We conducted a double-blind randomized control trial to investigate the impact of DHA+EPA supplementation on biomarkers related to neurotrauma and inflammation in American football participants. We used lipidomics to analyze changes in plasma lipid classes and molecular species following DHA+EPA supplementation. Additionally, we performed a neuroimaging study to evaluate changes in gray and white matter integrity throughout the American football season, comparing those with and without fish oil supplementation. To further understand the role RSHI play in structural and functional changes in the brain and the relationship between blood-based and neuroimaging biomarkers of brain injury, we conducted a pilot study involving mixed martial arts athletes. In this pilot study we examined the correlation between kinematic data from mouth guard sensors and neuroimaging data with blood-based biomarkers of brain injury before and after both contact and non-contact training sessions.Our research with collegiate American football athletes showed a notable increase in plasma concentrations of both DHA and EPA, specifically in molecular forms capable of crossing the blood-brain barrier following fish oil supplementation. Throughout the regular football season, we observed a significant rise in serum levels of neurofilament light, a biomarker indicating axonal injury. Neuroimaging results unveiled structural changes in the brain after a season of American football, affecting both white and gray matter pathways. Notably, fish oil supplementation did not alleviate the negative effects of RSHI, as reflected in neurofilament light plasma concentrations. However, participants with the highest plasma concentrations of DHA+EPA tended to exhibit lower neurofilament light concentrations. In our pilot study with mixed marital arts athletes, we established connections between immediate changes in brain hemodynamics (blood flow and brain strain), plasma neurofilament light concentrations, and head kinematics (number of impacts, impact angular acceleration, impact angular velocity), along with oxygenated hemoglobin concentrations after RSHI. Overall, our work underscores the importance of ongoing research combining neuroimaging and blood-based biomarkers in understanding and addressing brain injury risks in contact sports and the potential for fish oil supplementation to mitigate the trauma from RSHI.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798381097221Subjects--Topical Terms:

581367
Nutrition.
Subjects--Index Terms:

Brain injury Index Terms--Genre/Form:

554714
Electronic books.

Impact of Fish Oil Supplementation on Plasma Levels of Fatty Acid-Containing Lipid Classes, Lipid Molecular Species, and Biomarkers of Brain Injury in Contact Sport Athletes.
LDR:04803ntm a22004217 4500 001 1146884
005 20240812065034.5
006 m o d
007 cr bn ---uuuuu
008 250605s2023 xx obm 000 0 eng d
020 $a 9798381097221
035 $a (MiAaPQ)AAI30812507
035 $a AAI30812507
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Mullins, Veronica Anne. $3 1472422
245 1 0 $a Impact of Fish Oil Supplementation on Plasma Levels of Fatty Acid-Containing Lipid Classes, Lipid Molecular Species, and Biomarkers of Brain Injury in Contact Sport Athletes.
264 0 $c 2023
300 $a 1 online resource (129 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-06, Section: B.
500 $a Advisor: Chilton, Floyd Ski.
502 $a Thesis (Ph.D.)--The University of Arizona, 2023.
504 $a Includes bibliographical references
520 $a Contact sports involve a high risk of concussive injury and a higher risk of injury from repeated subconcussive head impacts (RSHI) that do not meet the threshold for a concussion diagnosis. RSHI increase an athlete's risk of biochemical and structural brain damage that can lead to cognitive and behavioral deficits later in life. Omega-3 highly unsaturated fatty acids, docosahexaenoic acids (DHA) and eicosapentaenoic acids (EPA), found in fish oil supplements and fatty fish, produce biologically active molecules that resolve inflammation and therefore their use in brain injury recovery has garnered substantial interest within the field of sports medicine research. The work reported in this dissertation was undertaken in response to the urgent need to better understand the risks of RSHI and the potential for omega-3 highly unsaturated fatty acids to mitigate the trauma. We conducted a double-blind randomized control trial to investigate the impact of DHA+EPA supplementation on biomarkers related to neurotrauma and inflammation in American football participants. We used lipidomics to analyze changes in plasma lipid classes and molecular species following DHA+EPA supplementation. Additionally, we performed a neuroimaging study to evaluate changes in gray and white matter integrity throughout the American football season, comparing those with and without fish oil supplementation. To further understand the role RSHI play in structural and functional changes in the brain and the relationship between blood-based and neuroimaging biomarkers of brain injury, we conducted a pilot study involving mixed martial arts athletes. In this pilot study we examined the correlation between kinematic data from mouth guard sensors and neuroimaging data with blood-based biomarkers of brain injury before and after both contact and non-contact training sessions.Our research with collegiate American football athletes showed a notable increase in plasma concentrations of both DHA and EPA, specifically in molecular forms capable of crossing the blood-brain barrier following fish oil supplementation. Throughout the regular football season, we observed a significant rise in serum levels of neurofilament light, a biomarker indicating axonal injury. Neuroimaging results unveiled structural changes in the brain after a season of American football, affecting both white and gray matter pathways. Notably, fish oil supplementation did not alleviate the negative effects of RSHI, as reflected in neurofilament light plasma concentrations. However, participants with the highest plasma concentrations of DHA+EPA tended to exhibit lower neurofilament light concentrations. In our pilot study with mixed marital arts athletes, we established connections between immediate changes in brain hemodynamics (blood flow and brain strain), plasma neurofilament light concentrations, and head kinematics (number of impacts, impact angular acceleration, impact angular velocity), along with oxygenated hemoglobin concentrations after RSHI. Overall, our work underscores the importance of ongoing research combining neuroimaging and blood-based biomarkers in understanding and addressing brain injury risks in contact sports and the potential for fish oil supplementation to mitigate the trauma from RSHI.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Nutrition. $3 581367
650 4 $a Neurosciences. $3 593561
650 4 $a Biomedical engineering. $3 588770
650 4 $a Medical imaging. $3 1180167
650 4 $a Biochemistry. $3 582831
653 $a Brain injury
653 $a Lipidomics
653 $a Docosahexaenoic acids
653 $a Lipids
653 $a Neuroimaging
655 7 $a Electronic books. $2 local $3 554714
690 $a 0570
690 $a 0317
690 $a 0541
690 $a 0574
690 $a 0487
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a The University of Arizona. $b Nutritional Sciences. $3 1472423
773 0 $t Dissertations Abstracts International $g 85-06B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30812507 $z click for full text (PQDT)