國立虎尾科技大學 |

Exploring the Many Scales of Neural Activity Underlying Perception and Decision Making.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Exploring the Many Scales of Neural Activity Underlying Perception and Decision Making./
Author:	Benson, Brandon.
Description:	1 online resource (170 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
Contained By:	Dissertations Abstracts International85-07B.
Subject:	Neurons. -
Online resource:	click for full text (PQDT)
ISBN:	9798381018318

Exploring the Many Scales of Neural Activity Underlying Perception and Decision Making.
Benson, Brandon.

Exploring the Many Scales of Neural Activity Underlying Perception and Decision Making. - 1 online resource (170 pages)

Source: Dissertations Abstracts International, Volume: 85-07, Section: B.

Thesis (Ph.D.)--Stanford University, 2023.

Includes bibliographical references

Experimental technologies that probe neural circuits from single neuron to brain-wide scales have allowed us to deepen our understanding of neural phenomena ranging from perception to decision making. For example in visual perception, orientation tuning in primary visual cortex (V1) has long been thought to play an important functional role in perception, but tests of this role have only recently been made possible through direct optogenetic stimulation of mouse cortex. Indeed, optogenetic stimulation reveals that a surprisingly small number of excited neurons (~20) can drive both large-scale neural ensembles (~1000) and perception. We develop a mean field neural circuit theory for how such small stimulation can create large responses. Our theory also explains constraints on avalanche like behavior widely observed in the spontaneous activity of many species. We further study decision-making at a global-brain scale leveraging multi-region neuropixel recordings collected across a collaboration of 11 experimental labs (part of "the International Brain Lab" (IBL)). We analyzed a massive dataset consisting of the neural activity of 300,000 neurons in mice performing a decision making task and developed techniques to elucidate the contribution of many different brain regions to decision making. Through decoding analyses, we discovered that task and behavioral variables can be decoded from regions which are both classically known as well as other regions which are functionally surprising. Overall, through theoretical analysis of unprecedented datasets, we propose a mechanism for perception in V1 and uncover region-specific details of brain-wide activity underlying decision making.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798381018318Subjects--Topical Terms:

581309
Neurons.
Index Terms--Genre/Form:

554714
Electronic books.

Exploring the Many Scales of Neural Activity Underlying Perception and Decision Making.
LDR:02952ntm a22003257 4500 001 1148738
005 20240930100132.5
006 m o d
007 cr bn ---uuuuu
008 250605s2023 xx obm 000 0 eng d
020 $a 9798381018318
035 $a (MiAaPQ)AAI30726767
035 $a (MiAaPQ)STANFORDwp132vx8882
035 $a AAI30726767
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Benson, Brandon. $3 1474781
245 1 0 $a Exploring the Many Scales of Neural Activity Underlying Perception and Decision Making.
264 0 $c 2023
300 $a 1 online resource (170 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
500 $a Advisor: Ganguli, Surya;Baccus, Stephen;Good, Benjamin.
502 $a Thesis (Ph.D.)--Stanford University, 2023.
504 $a Includes bibliographical references
520 $a Experimental technologies that probe neural circuits from single neuron to brain-wide scales have allowed us to deepen our understanding of neural phenomena ranging from perception to decision making. For example in visual perception, orientation tuning in primary visual cortex (V1) has long been thought to play an important functional role in perception, but tests of this role have only recently been made possible through direct optogenetic stimulation of mouse cortex. Indeed, optogenetic stimulation reveals that a surprisingly small number of excited neurons (~20) can drive both large-scale neural ensembles (~1000) and perception. We develop a mean field neural circuit theory for how such small stimulation can create large responses. Our theory also explains constraints on avalanche like behavior widely observed in the spontaneous activity of many species. We further study decision-making at a global-brain scale leveraging multi-region neuropixel recordings collected across a collaboration of 11 experimental labs (part of "the International Brain Lab" (IBL)). We analyzed a massive dataset consisting of the neural activity of 300,000 neurons in mice performing a decision making task and developed techniques to elucidate the contribution of many different brain regions to decision making. Through decoding analyses, we discovered that task and behavioral variables can be decoded from regions which are both classically known as well as other regions which are functionally surprising. Overall, through theoretical analysis of unprecedented datasets, we propose a mechanism for perception in V1 and uncover region-specific details of brain-wide activity underlying decision making.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Neurons. $3 581309
650 4 $a Decision making. $3 528319
650 4 $a Neurosciences. $3 593561
655 7 $a Electronic books. $2 local $3 554714
690 $a 0317
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Stanford University. $3 1184533
773 0 $t Dissertations Abstracts International $g 85-07B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30726767 $z click for full text (PQDT)