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Growth Factor Regulation of Neuroblastoma Migration and Invasion.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Growth Factor Regulation of Neuroblastoma Migration and Invasion./
Author:	Park, Jenna.
Description:	1 online resource (79 pages)
Notes:	Source: Masters Abstracts International, Volume: 85-05.
Contained By:	Masters Abstracts International85-05.
Subject:	Medicine. -
Online resource:	click for full text (PQDT)
ISBN:	9798380832816

Growth Factor Regulation of Neuroblastoma Migration and Invasion.
Park, Jenna.

Growth Factor Regulation of Neuroblastoma Migration and Invasion. - 1 online resource (79 pages)

Source: Masters Abstracts International, Volume: 85-05.

Thesis (M.Sc.)--University of Toronto (Canada), 2023.

Includes bibliographical references

Neuroblastoma (NB) is the most common extracranial pediatric cancer with a five-year survival rate of less than 50%. It arises from neural crest precursors in tissues such as the adrenal gland. Metastatic NB is often fatal with common sites including bone, bone marrow and brain. Our laboratory previously developed a mouse model of NB to study metastasis to the bone and the brain, isolated tumor cells from these metastatic sites and identified genes regulating their metastatic behavior. Since neural crest-derived cells often use receptor tyrosine kinases (RTKs) and their ligands to proliferate and migrate, I hypothesized that NB cells also use these proteins to metastasize. To address this, I performed mass spectroscopy analysis of NB cell surface proteins and scRNA-seq to identify RTKs and their ligands enriched in hypermetastatic NB cells as compared to less metastatic parental cells. I identified four RTKs, PDGFRA, PDGFRB, EGFR, and FGFR1 and found that the PDGFRB ligand PDGFBB mediated the migration and invasion of the hypermetastatic cells without markedly affecting the parental cells. These findings suggest that NB cells use PDGF to mediate part of the metastatic process.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798380832816Subjects--Topical Terms:

644133
Medicine.
Subjects--Index Terms:

CancerIndex Terms--Genre/Form:

554714
Electronic books.

Growth Factor Regulation of Neuroblastoma Migration and Invasion.
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500 $a Advisor: Irwin, Meredith.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2023.
504 $a Includes bibliographical references
520 $a Neuroblastoma (NB) is the most common extracranial pediatric cancer with a five-year survival rate of less than 50%. It arises from neural crest precursors in tissues such as the adrenal gland. Metastatic NB is often fatal with common sites including bone, bone marrow and brain. Our laboratory previously developed a mouse model of NB to study metastasis to the bone and the brain, isolated tumor cells from these metastatic sites and identified genes regulating their metastatic behavior. Since neural crest-derived cells often use receptor tyrosine kinases (RTKs) and their ligands to proliferate and migrate, I hypothesized that NB cells also use these proteins to metastasize. To address this, I performed mass spectroscopy analysis of NB cell surface proteins and scRNA-seq to identify RTKs and their ligands enriched in hypermetastatic NB cells as compared to less metastatic parental cells. I identified four RTKs, PDGFRA, PDGFRB, EGFR, and FGFR1 and found that the PDGFRB ligand PDGFBB mediated the migration and invasion of the hypermetastatic cells without markedly affecting the parental cells. These findings suggest that NB cells use PDGF to mediate part of the metastatic process.
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653 $a Receptor tyrosine kinases
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