國立虎尾科技大學 |

Brain Injury and Pain Exposure Are Associated with Alterations in Structural Connectivity and Neurodevelopment in Very Preterm Infants.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Brain Injury and Pain Exposure Are Associated with Alterations in Structural Connectivity and Neurodevelopment in Very Preterm Infants./
Author:	Selvanathan, Thiviya.
Description:	1 online resource (250 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-05, Section: B.
Contained By:	Dissertations Abstracts International85-05B.
Subject:	Neurosciences. -
Online resource:	click for full text (PQDT)
ISBN:	9798380834964

Brain Injury and Pain Exposure Are Associated with Alterations in Structural Connectivity and Neurodevelopment in Very Preterm Infants.
Selvanathan, Thiviya.

Brain Injury and Pain Exposure Are Associated with Alterations in Structural Connectivity and Neurodevelopment in Very Preterm Infants. - 1 online resource (250 pages)

Source: Dissertations Abstracts International, Volume: 85-05, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2023.

Includes bibliographical references

Preterm infants undergo neonatal intensive care during a period of maturation of structural brain networks, which may be affected by clinical illness and exposures such as brain injury and pain. This thesis explores (1) the impacts of brain injury and pain on development of structural connectivity and neurodevelopmental outcomes, and (2) whether aberrations in structural connectivity are an important mediator of outcomes. A prospective cohort of very preterm infants underwent early-life and term-equivalent age brain MRI to assess brain injury and structural connectivity. Exposure to pain was quantified as number of invasive procedures. Neurodevelopmental outcomes were assessed at 18 months corrected age with the Bayley Scales of Infant and Toddler Development, Third edition. Brain injuries were segmented to quantify volumes and develop voxel-wise lesion-symptom maps to assess relationships between brain injury size and location with neurodevelopmental outcomes. These data were combined with data of structural connectivity to develop voxel-wise disconnection-symptom maps that assessed relationships between brain injury size and location with aberrations in structural connectivity and neurodevelopmental outcomes. These maps revealed that brain injury involving tracts passing through the basal ganglia, thalamus and pons were associated with poorer neurodevelopmental outcomes. This highlights the importance of considering brain injury relative to white matter tracts when predicting neurodevelopmental outcomes. Greater early-life pain was associated with poorer neurodevelopmental outcomes, and potentially mediated by alterations in neonatal structural connectivity. Specifically, greater invasive procedures were associated with widespread reductions in structural brain connectivity, and reduced connectivity was associated with poorer neurodevelopmental outcomes with specificity for the striatum. The relationship between greater early-life pain and adverse neurodevelopmental outcomes was modified by duration of morphine exposure. However, morphine exposure was not associated with neonatal structural connectivity suggesting that morphine may modify neurodevelopmental outcomes through alternative mechanisms. Finally, associations observed between pain and brain injury, aberrant connectivity within the striatum, and neurodevelopmental outcomes highlight a potential vulnerability of this region to clinical illness and exposures during early brain development in very preterm infants. These data also suggest that the striatum may play an important role in neurodevelopment in this population; this warrants further study.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798380834964Subjects--Topical Terms:

593561
Neurosciences.
Subjects--Index Terms:

Brain injuryIndex Terms--Genre/Form:

554714
Electronic books.

Brain Injury and Pain Exposure Are Associated with Alterations in Structural Connectivity and Neurodevelopment in Very Preterm Infants.
LDR:04117ntm a22004097 4500 001 1151864
005 20241118135847.5
006 m o d
007 cr mn ---uuuuu
008 250605s2023 xx obm 000 0 eng d
020 $a 9798380834964
035 $a (MiAaPQ)AAI30640386
035 $a AAI30640386
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Selvanathan, Thiviya. $3 1478700
245 1 0 $a Brain Injury and Pain Exposure Are Associated with Alterations in Structural Connectivity and Neurodevelopment in Very Preterm Infants.
264 0 $c 2023
300 $a 1 online resource (250 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-05, Section: B.
500 $a Advisor: Miller, Steven;Ibrahim, George.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2023.
504 $a Includes bibliographical references
520 $a Preterm infants undergo neonatal intensive care during a period of maturation of structural brain networks, which may be affected by clinical illness and exposures such as brain injury and pain. This thesis explores (1) the impacts of brain injury and pain on development of structural connectivity and neurodevelopmental outcomes, and (2) whether aberrations in structural connectivity are an important mediator of outcomes. A prospective cohort of very preterm infants underwent early-life and term-equivalent age brain MRI to assess brain injury and structural connectivity. Exposure to pain was quantified as number of invasive procedures. Neurodevelopmental outcomes were assessed at 18 months corrected age with the Bayley Scales of Infant and Toddler Development, Third edition. Brain injuries were segmented to quantify volumes and develop voxel-wise lesion-symptom maps to assess relationships between brain injury size and location with neurodevelopmental outcomes. These data were combined with data of structural connectivity to develop voxel-wise disconnection-symptom maps that assessed relationships between brain injury size and location with aberrations in structural connectivity and neurodevelopmental outcomes. These maps revealed that brain injury involving tracts passing through the basal ganglia, thalamus and pons were associated with poorer neurodevelopmental outcomes. This highlights the importance of considering brain injury relative to white matter tracts when predicting neurodevelopmental outcomes. Greater early-life pain was associated with poorer neurodevelopmental outcomes, and potentially mediated by alterations in neonatal structural connectivity. Specifically, greater invasive procedures were associated with widespread reductions in structural brain connectivity, and reduced connectivity was associated with poorer neurodevelopmental outcomes with specificity for the striatum. The relationship between greater early-life pain and adverse neurodevelopmental outcomes was modified by duration of morphine exposure. However, morphine exposure was not associated with neonatal structural connectivity suggesting that morphine may modify neurodevelopmental outcomes through alternative mechanisms. Finally, associations observed between pain and brain injury, aberrant connectivity within the striatum, and neurodevelopmental outcomes highlight a potential vulnerability of this region to clinical illness and exposures during early brain development in very preterm infants. These data also suggest that the striatum may play an important role in neurodevelopment in this population; this warrants further study.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Neurosciences. $3 593561
650 4 $a Pediatrics. $3 644839
650 4 $a Developmental biology. $3 669036
653 $a Brain injury
653 $a Brain networks
653 $a Neurodevelopment
653 $a Neuroimaging
653 $a Pain
653 $a Prematurity
655 7 $a Electronic books. $2 local $3 554714
690 $a 0317
690 $a 0767
690 $a 0758
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Toronto (Canada). $b Medical Science. $3 1181466
773 0 $t Dissertations Abstracts International $g 85-05B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30640386 $z click for full text (PQDT)