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Probing Associations Between Adolescent Alcohol Use, Behavioral Flexibility, and Underlying Neurocircuitry Among Adults.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Probing Associations Between Adolescent Alcohol Use, Behavioral Flexibility, and Underlying Neurocircuitry Among Adults./
Author:	Vidrascu, Elena M.
Description:	1 online resource (187 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
Contained By:	Dissertations Abstracts International85-11B.
Subject:	Neurosciences. -
Online resource:	click for full text (PQDT)
ISBN:	9798382631035

Probing Associations Between Adolescent Alcohol Use, Behavioral Flexibility, and Underlying Neurocircuitry Among Adults.
Vidrascu, Elena M.

Probing Associations Between Adolescent Alcohol Use, Behavioral Flexibility, and Underlying Neurocircuitry Among Adults. - 1 online resource (187 pages)

Source: Dissertations Abstracts International, Volume: 85-11, Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2024.

Includes bibliographical references

Animal studies have highlighted the deficits on behavioral flexibility resulting from adolescent alcohol exposure, and recent research from human models suggests that adolescent binge drinking increases a form of inflexible behavior: attentional bias towards alcohol- and non-drug-related stimuli. The goal of the present dissertation was to first examine behavioral inflexibility among adults with and without a history of adolescent alcohol use, followed by underlying neurocircuitry. We explored total attentional bias and its subcomponents and first found that attentional capture and disengagement failure were negatively correlated with one another. We further explored the interaction effects of adolescent and current alcohol use and found that greater sensitivity to reward conditioning was associated with greater attentional capture by rewarded-conditioned cues among adults without a history of adolescent alcohol use. In contrast, among adults with a history of adolescent alcohol use, greater sensitivity was associated with greater attentional hold by reward-conditioned cues. We also discovered that adults with a history of adolescent alcohol use exhibited heightened habitual action selection. When exploring the circuitry underlying inflexible behavior, we first found that adult heavy drinkers with a history of adolescent alcohol use had reduced functional connectivity among regions in the executive and salience networks, and striatal regions, reminiscent of rodent data. We also observed an overlap of functionally connected regions associated with elevations in both attentional hold by reward-conditioned cues and habitual action selection. Furthermore, we observed less activity in the lateral occipital cortex during attentional hold among adults with a history of adolescent alcohol use, as well as increased activity in the anterior cingulate cortex during attentional capture. Together, these results suggest inefficient communication within frontostriatal circuits important for goal-directed attention in association with adolescent alcohol use and suggests further investigation into the effects of adolescent alcohol use on adulthood flexibility. More broadly, these findings are congruent with rodent models of adolescent intermittent ethanol exposure leading to impaired flexibility in adulthood. Further, these task paradigms provide the opportunity to explore the neurobiology of these forms of behavioral inflexibility and whether interventions implemented in adulthood or at earlier stages in life can mitigate such inflexibility.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798382631035Subjects--Topical Terms:

593561
Neurosciences.
Subjects--Index Terms:

Adolescent alcohol useIndex Terms--Genre/Form:

554714
Electronic books.

Probing Associations Between Adolescent Alcohol Use, Behavioral Flexibility, and Underlying Neurocircuitry Among Adults.
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