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Science, technology, and medicine in modern history = from proteins to DNA, 1945-2000 /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Science, technology, and medicine in modern history/ Miguel Garc�ia-Sancho.
Reminder of title:	from proteins to DNA, 1945-2000 /
Author:	Garc�ia-Sancho, Miguel,
Published:	New York :Palgrave Macmillan, : 2012.,
Description:	1 online resource (242 p.) :ill. :
Subject:	Nucleotide sequence - Data processing. -
Online resource:	http://www.palgraveconnect.com/doifinder/10.1057/9780230370937
ISBN:	9780230370937 (electronic bk.)

Science, technology, and medicine in modern history = from proteins to DNA, 1945-2000 /
Garc�ia-Sancho, Miguel,1978-

Science, technology, and medicine in modern historyfrom proteins to DNA, 1945-2000 /[electronic resource] :Miguel Garc�ia-Sancho. - New York :Palgrave Macmillan,2012. - 1 online resource (242 p.) :ill.

Includes bibliographical references (203-230).

Introduction: An Historical Approach to Sequencing -- PART I: EMERGENCE: FREDERICK SANGER'S PIONEERING TECHNIQUES (1943-1977) -- The Sequence of Insulin and the Configuration of a New Biochemical Form of Work (1943-1962) -- From Chemical Degradation to Biological Replication (1962-1977) -- PART II: MECHANISATION b6 s 1: COMPUTING AND THE AUTOMATION OF SEQUENCE RECONSTRUCTION (1962-1987) -- Sequencing Software and the Shift in the Practice of Computation -- Sequence Databases and the Emergence of 'Information Engineers' -- PART III: MECHANISATION b6 s 2: THE SEQUENCER AND THE AUTOMATION OF SEQUENCE CONSTRUCTION (1980-2000) -- A New Approach to Sequencing at Caltech -- The Commercialisation of the DNA Sequencer -- Conclusions: A Long History of Practices -- Appendix 1: Oral Histories -- Appendix 2: Archival Sources.

When we talk about DNA sequencing, it is the relatively recent Human Genome Project and the so-called 'genomics revolution' which immediately come to mind. However, sequencing has a longer and more complex history which penetrates key issues of post-World War II biomedicine, such as the interplay of protein chemistry and molecular biology, and the growing interaction between biology and computing. In this, the first academic history of sequencing, Miguel Gar�ca-Sancho follows the development of this form of molecular analysis to offer a new insight into the development of biomedicine during the second half of the twentieth century. He explores the emergence of the first protein and DNA techniques, the development of sequencing software and databases, and the commercialisation of the first automatic sequencers by the company Applied Biosystems. This vital historical perspective will allow both professionals and scholars to think rather differently about the emerging fields of bioinformatics and biotechnology, as well as the impact of biomedicine on modern society more broadly.

ISBN: 9780230370937 (electronic bk.)

Source: 407774Palgrave Macmillanhttp://www.palgraveconnect.comSubjects--Topical Terms:

670311
Nucleotide sequence
--Data processing.Index Terms--Genre/Form:

554714
Electronic books.

LC Class. No.: QP620 / .G37 2012

Dewey Class. No.: 572/.65

Science, technology, and medicine in modern history = from proteins to DNA, 1945-2000 /
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505 0 $a Introduction: An Historical Approach to Sequencing -- PART I: EMERGENCE: FREDERICK SANGER'S PIONEERING TECHNIQUES (1943-1977) -- The Sequence of Insulin and the Configuration of a New Biochemical Form of Work (1943-1962) -- From Chemical Degradation to Biological Replication (1962-1977) -- PART II: MECHANISATION b6 s 1: COMPUTING AND THE AUTOMATION OF SEQUENCE RECONSTRUCTION (1962-1987) -- Sequencing Software and the Shift in the Practice of Computation -- Sequence Databases and the Emergence of 'Information Engineers' -- PART III: MECHANISATION b6 s 2: THE SEQUENCER AND THE AUTOMATION OF SEQUENCE CONSTRUCTION (1980-2000) -- A New Approach to Sequencing at Caltech -- The Commercialisation of the DNA Sequencer -- Conclusions: A Long History of Practices -- Appendix 1: Oral Histories -- Appendix 2: Archival Sources.
520 $a When we talk about DNA sequencing, it is the relatively recent Human Genome Project and the so-called 'genomics revolution' which immediately come to mind. However, sequencing has a longer and more complex history which penetrates key issues of post-World War II biomedicine, such as the interplay of protein chemistry and molecular biology, and the growing interaction between biology and computing. In this, the first academic history of sequencing, Miguel Gar�ca-Sancho follows the development of this form of molecular analysis to offer a new insight into the development of biomedicine during the second half of the twentieth century. He explores the emergence of the first protein and DNA techniques, the development of sequencing software and databases, and the commercialisation of the first automatic sequencers by the company Applied Biosystems. This vital historical perspective will allow both professionals and scholars to think rather differently about the emerging fields of bioinformatics and biotechnology, as well as the impact of biomedicine on modern society more broadly.
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