國立虎尾科技大學 |

Safety and efficacy of gene-based therapeutics for inherited disorders

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Safety and efficacy of gene-based therapeutics for inherited disorders/ edited by Nicola Brunetti-Pierri.
other author:	Brunetti-Pierri, Nicola.
Published:	Cham :Springer International Publishing : : 2017.,
Description:	ix, 220 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Genetic disorders - Gene therapy. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-53457-2
ISBN:	9783319534572

Safety and efficacy of gene-based therapeutics for inherited disorders
Safety and efficacy of gene-based therapeutics for inherited disorders[electronic resource] /edited by Nicola Brunetti-Pierri. - Cham :Springer International Publishing :2017. - ix, 220 p. :ill., digital ;24 cm.

Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors.

In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields.

ISBN: 9783319534572

Standard No.: 10.1007/978-3-319-53457-2doiSubjects--Topical Terms:

1142090
Genetic disorders
--Gene therapy.

LC Class. No.: RB155.8

Dewey Class. No.: 616.042

Safety and efficacy of gene-based therapeutics for inherited disorders
LDR:02541nam a2200313 a 4500 001 885103
003 DE-He213
005 20170523142517.0
006 m d
007 cr nn 008maaau
008 180530s2017 gw s 0 eng d
020 $a 9783319534572 $q (electronic bk.)
020 $a 9783319534558 $q (paper)
024 7 $a 10.1007/978-3-319-53457-2 $2 doi
035 $a 978-3-319-53457-2
040 $a GP $c GP
041 0 $a eng
050 4 $a RB155.8
072 7 $a MMG $2 bicssc
072 7 $a MED071000 $2 bisacsh
082 0 4 $a 616.042 $2 23
090 $a RB155.8 $b .S128 2017
245 0 0 $a Safety and efficacy of gene-based therapeutics for inherited disorders $h [electronic resource] / $c edited by Nicola Brunetti-Pierri.
260 $a Cham : $c 2017. $b Springer International Publishing : $b Imprint: Springer,
300 $a ix, 220 p. : $b ill., digital ; $c 24 cm.
505 0 $a Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors.
520 $a In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields.
650 0 $a Genetic disorders $x Gene therapy. $3 1142090
650 0 $a Genetic transformation. $3 862279
650 1 4 $a Biomedicine. $3 593880
650 2 4 $a Pharmacology/Toxicology. $3 593882
650 2 4 $a Gene Therapy. $3 580629
650 2 4 $a Molecular Medicine. $3 668353
700 1 $a Brunetti-Pierri, Nicola. $3 1142089
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-53457-2
950 $a Biomedical and Life Sciences (Springer-11642)